38824-10-1

Basic information

• Product Name: N-[2-(3-methoxybenzoyl)phenyl]acetamide
• CAS NO: 38824-10-1
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.2952
• Mol File: 38824-10-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 516.2°C at 760 mmHg
• Flash Point: 266°C
• Density: 1.198g/cm³
• Vapor Pressure: 9.19E-11mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: N-[2-(3-methoxybenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(3-methoxybenzoyl)phenyl]acetamide(38824-10-1)
• EPA Substance Registry System: N-[2-(3-methoxybenzoyl)phenyl]acetamide(38824-10-1)

Safety Data

• Hazardous Substances Data: 38824-10-1(Hazardous Substances Data)

Upstream product

• 6971-51-3 3-methoxybenzyl alcohol 
• 103-84-4 Acetanilid 
• 62-53-3 aniline 
• 19591-17-4 o-iodoacetanilide 
• 591-31-1 3-methoxy-benzaldehyde 
• 100-84-5 1-methoxy-3-methyl-benzene 

Downstream Products

• 38824-11-2 (2-aminophenyl)-(3-methoxyphenyl)methanone 
• 65848-66-0 4-(3-methoxyphenyl)-1H-quinolin-2-one 

Relevant articles and documents

Palladium Catalyzed Direct Acylation of Iodo-Acetanilides/Iodo-Phenyl Acetates: Domino One-Pot Synthesis of 2-Quinolinones

Pd-catalyzed direct acylation reaction of iodoacetanilides/iodophenyl acetates with aldehydes is presented. Simple, bench-top aldehydes were used as non-toxic acylating agents. This protocol comprises direct coupling with aldehydes without activating the carbonyl group and without directing group assistance. The strategy was applied to a domino one-pot synthesis of 2-quinolinones through acylation and intramolecular aldol condensation. Significantly, the strategy was extended to the domino one-pot synthesis of drugs and bioactive compounds.

Palladium-catalyzed oxidative C-H bond acylation of acetanilides with benzylic alcohols

An efficient and clean method to construct C-C bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert-butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in the presence of triflic acid (TfOH). The acylation reactions exhibit excellent reactivities, and up to 95% yield of the corresponding aryl ketone could be obtained under the optimal conditions. Copyright