38824-75-8Relevant academic research and scientific papers
Facile and efficient synthesis of 4-alkyl derivatives of 3-carbamoyl- and 3,5-dicarbamoylpyridines as nicotinamide mimetics
Di Rienzo, Barbara,Mellini, Paolo,Tortorella, Silvano,De Vita, Daniela,Scipione, Luigi
, p. 3835 - 3838 (2010)
Nicotinamide plays a key role in many biological processes and, as a consequence, its derivatives could be attractive for the synthesis of biologically active compounds. Here a rapid and efficient way of preparing alkyl derivatives of nicotinamide, precisely, 4-alkyl-3-carbamoylpyridine and 4-alkyl-3,5-dicarbamoylpyridine is reported. The synthetic route developed adopts mild reaction conditions and produces target compounds in higher yields compared with methods described in literature. Georg Thieme Verlag Stuttgart · New York.
SOLUBLE FORMS OF INCLUSION COMPLEXES OF HISTONE DEACETYLASE INHIBITORS AND CYCLODEXTRINS, THEIR PREPARATION PROCESSES AND USES IN THE PHARMACEUTICAL FIELD
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Page/Page column 22; 23, (2008/12/07)
The invention relates to the preparation of soluble forms of complexes of histone deacetylase inhibitors and cyclodextrins. The preparation process involves the formation of inclusion complexes with cyclodextrins with the aid of microwaves. Their use is in the pharmaceutical field.
