38829-70-8Relevant academic research and scientific papers
Selective Synthesis of N-Unsubstituted and N-Arylindoles by the Reaction of Arynes with Azirines
Thangaraj, Manikandan,Bhojgude, Sachin Suresh,Jain, Shailja,Gonnade, Rajesh G.,Biju, Akkattu T.
, p. 8604 - 8611 (2016)
The transition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines allowing the synthesis of either N-unsubstituted or N-arylindoles has been developed. At 60 °C, arynes generated from 2-(trimethylsilyl)aryl triflates smoothly insert into 2H-azirines to form 2,3-diarylindoles with high selectivity. Interestingly, when the reaction was performed at -10 °C, the selectivity was switched to the formation of 1,2,3-triarylindoles in good yields.
