38829-72-0Relevant academic research and scientific papers
Step and redox efficient nitroarene to indole synthesis
?zkaya, Bünyamin,Bub, Christina L.,Patureau, Frederic W.
supporting information, p. 13185 - 13188 (2020/11/09)
Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed, in sharp contrast to the rich literature on the construction of indoles. Elemental zinc was found to be the best terminal reductant. This journal is
Rhodium(III)-Catalyzed Redox-Neutral C-H Annulation of Arylnitrones and Alkynes for the Synthesis of Indole Derivatives
Zhou, Zhi,Liu, Guixia,Chen, Yan,Lu, Xiyan
supporting information, p. 2944 - 2950 (2015/09/28)
By using a nitrone as the oxidizing directing group, a mild, practical and efficient rhodium(III)-catalyzed C-H functionalization for the synthesis of indole derivatives has been developed. This reaction obviates the need for an external oxidant and shows good functional group tolerance. The employment of a sterically hindered Mes group on the carbon center of the nitrone is crucial to produce indoles in high yield.
Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: Redox-neutral and traceless by N-N bond cleavage
Zhao, Dongbing,Shi, Zhuangzhi,Glorius, Frank
, p. 12426 - 12429 (2013/12/04)
Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same retrosynthetic disconnection but is based on a RhIII-catalyzed directed C-H activation step and a successive coupling with alkynes. Copyright
