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60481-51-8

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60481-51-8 Usage

Chemical Properties

White to pink or beige-brown powder

Uses

3,4-Dimethylphenylhydrazine hydrochloride, is used as a reactant with ethyl 3-ethoxy-2-ethoxycarbonylprop-2-enoate to produce 2-(3,4-dimethyl-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylic acid ethyl ester. This reaction will need reagent K2CO3, and the menstruum ethanol.

Check Digit Verification of cas no

The CAS Registry Mumber 60481-51-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,4,8 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60481-51:
(7*6)+(6*0)+(5*4)+(4*8)+(3*1)+(2*5)+(1*1)=108
108 % 10 = 8
So 60481-51-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2/c1-6-3-4-8(10-9)5-7(6)2/h3-5,10H,9H2,1-2H3

60481-51-8 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A13027)  3,4-Dimethylphenylhydrazine hydrochloride, 98%   

  • 60481-51-8

  • 10g

  • 603.0CNY

  • Detail
  • Alfa Aesar

  • (A13027)  3,4-Dimethylphenylhydrazine hydrochloride, 98%   

  • 60481-51-8

  • 50g

  • 1593.0CNY

  • Detail
  • Alfa Aesar

  • (A13027)  3,4-Dimethylphenylhydrazine hydrochloride, 98%   

  • 60481-51-8

  • 250g

  • 6779.0CNY

  • Detail
  • Aldrich

  • (540455)  3,4-Dimethylphenylhydrazinehydrochloride  97%

  • 60481-51-8

  • 540455-25G

  • 3,016.26CNY

  • Detail

60481-51-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,4-Dimethylphenylhydrazine hydrochloride

1.2 Other means of identification

Product number -
Other names (3,4-dimethyl-phenyl)-hydrazine,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60481-51-8 SDS

60481-51-8Relevant articles and documents

Method for synthesizing eltrombopag by using micro-channel reactor

-

Paragraph 0035; 0052-0070; 0086-0087, (2021/04/14)

The invention discloses a method for synthesizing eltrombopag by using a micro-channel reactor. The method comprises the following steps: S1, material synthesis: adding a raw material 3, 4-dimethylaniline into an acid aqueous solution, dissolving to obtain a material I, dissolving sodium nitrite into water to obtain a material II, dissolving sodium hydrogen sulfite and sodium hydroxide into water to obtain a material III, taking a solution prepared from hydrochloric acid and water as a material IV, adding a raw material 3-amino-2 hydroxyl-[1, 1-biphenyl]-3 formic acid into the acid aqueous solution, dissolving to obtain a material V, and dissolving sodium nitrite into water to obtain a material VI; s2, introducing the material into the micro-channel reactor S3 to obtain a first intermediate 3, 4-dimethylphenylhydrazine hydrochloride, and reacting with ethyl acetoacetate to obtain a second intermediate 2-(3, 4-dimethylphenyl)-5-methyl-1H-pyrazole-3 (2H)-ketone; and S4, introducing the material V and the material VI into the micro-channel reactor for reaction, and enabling the effluent reaction liquid to directly flow into a reaction bottle filled with a 2-(3, 4-dimethylphenyl)-5-methyl-1H-pyrazole-3 (2H)-ketone solution, thereby obtaining eltrombopag.

Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water

Kumar, Siripuram Vijay,Ma, Dawei

supporting information, p. 1003 - 1006 (2018/09/20)

The N,N’-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 oC in water under the assistance of K3PO4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.

Facile and convenient synthesis of aryl hydrazines via copper-catalyzed C-N cross-coupling of aryl halides and hydrazine hydrate

Kurandina, Daria V.,Eliseenkov, Eugene V.,Ilyin, Petr V.,Boyarskiy, Vadim P.

, p. 4043 - 4048 (2014/06/09)

An efficient and convenient method for the synthesis of aryl hydrazines has been developed via copper-catalyzed cross-coupling of aryl bromides and hydrazine with a readily accessible ligand and water as a solvent. The multigram scale procedure is applicable to aryl bromides bearing both moderately electron-donating and electron-withdrawing substituents in the aromatic nucleus. No column chromatography is required to obtain aryl hydrazine hydrochlorides in good yields.

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