3883-58-7

Basic information

• Product Name: 2,2-Dimethyl-1,3-cyclopentanedione
• Synonyms: 2,2-Dimethyl-1,3-cyclopentanedione
• CAS NO: 3883-58-7
• Molecular Formula: C₇H₁₀O₂
• Molecular Weight: 126.15
• Mol File: 3883-58-7.mol
• Article Data: 22

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 213.4°C at 760 mmHg
• Flash Point: 76.5°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.164mmHg at 25°C
• Refractive Index: 1.455
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2,2-Dimethyl-1,3-cyclopentanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-1,3-cyclopentanedione(3883-58-7)
• EPA Substance Registry System: 2,2-Dimethyl-1,3-cyclopentanedione(3883-58-7)

Safety Data

• Hazardous Substances Data: 3883-58-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 1362, 1983 DOI: 10.1021/jo00156a046

InChI:InChI=1/C7H10O2/c1-7(2)5(8)3-4-6(7)9/h3-4H2,1-2H3

Upstream product

• 765-69-5 2-Methylcyclopentane-1,3-dione 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 3142-58-3 3,3-dimethyl-2,4-pentanedione 
• 86439-24-9 Diethyl 2,2-dimethyl-3-oxohexanedioate 
• 2916-31-6 2,2-dimethyl-1,3-dioxolane 
• 17082-61-0 1,2-bis(trimethylsiloxy)cyclobutene 
• 695-30-7 2,2-dimethyl-1,3-dioxane 
• 5870-63-3 3-hydroxy-2-methyl-2-cyclopenten-1-one 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 
• 57613-21-5 3,3-Dimethyl-2,4-dioxo-cyclopentanecarboxylic acid ethyl ester 
• 767-55-5 2,2,5,5-tetramethyl-1,3-dioxane 
• 676-88-0 dimethyl(methylthio)sulfonium tetrafluoroborate 

Downstream Products

• 54857-48-6 ethyl 5-methyl-4-oxohexanoate 

Relevant articles and documents

Synthesis of 2,2-dimethyl-4-cyclopentene-1,3-dione and 5,5-dimethyl-4-hydroxy-2-cyclopenten-1-one

Enedione 1 and related rac- and optically active enones 2 bearing a hydroxyl- 2a or a protected- 2b-c or an activated - 2d 4-hydroxyl group at C-4 have been efficiently synthesized from cheap and readily available starting materials.

Selective Derivatization of N-Terminal Cysteines Using Cyclopentenediones

The outcome of the Michael-type reaction between thiols and 2,2-disubstituted cyclopentenediones varies depending on the thiol. Stable compounds with two fused rings were formed upon reaction with 1,2-aminothiols (such as N-terminal cysteines in peptides). Other thiols gave reversibly Michael-type adducts that were in equilibrium with the starting materials. This differential reactivity allows differently placed cysteines to be distinguished and has been exploited to prepare bioconjugates incorporating two or three different moieties.

Methods of treating soft tissue defects

The specification discloses compositions and methods for treating a soft tissue defect of an individual.

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold. Preliminary studies identified (R)-(2,2-dimethylcyclopentyl)amine as a preferred C4 substituent on the pyrrolopyridazi