38838-27-6

Basic information

• Product Name: N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide
• CAS NO: 38838-27-6
• Molecular Formula: C₂₀H₂₂INO₅
• Molecular Weight: 483.2969
• Mol File: 38838-27-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 615.8°C at 760 mmHg
• Flash Point: 326.2°C
• Density: 1.61g/cm³
• Vapor Pressure: 9.36E-16mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide(38838-27-6)
• EPA Substance Registry System: N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide(38838-27-6)

Safety Data

• Hazardous Substances Data: 38838-27-6(Hazardous Substances Data)

Usage

General Description

N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide is a complex chemical compound with a long and intricate name. It contains an amide group and is derived from a dibenzo annulene structure, which is composed of two benzene rings fused together. The presence of an iodo group and multiple methoxy groups in the compound suggests that it may have pharmacological or biological activities. The specific properties and uses of N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulen-5-yl)acetamide would likely need to be determined through further research and experimentation.

Upstream product

• 477-27-0 colchiceine 
• 64-86-8 colchicine 

Relevant articles and documents

Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin

We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously synthesized molecules. To achieve the irreversible binding of the agent to the cysteine residues of the colchicine site of tubulin protein, we synthesized a number of new allocolchicinoids bearing the acceptor moiety. Some of the new derivatives possess cytotoxic activity against COLO-357, BxPC-3, HaCaT, and HEK293 cell lines in a low nanomolar range of concentrations. A substoichiometric mode of microtubule assembly inhibition was demonstrated. The most active compounds possess close to colchicine general toxicity on mice. This journal is

Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity

Two series of heterocyclic colchicinoids bearing β-methylenedihydrofuran or 2H-pyran-2-one fragments were synthesized by the intramolecular Heck reaction. Methylenedihydrofuran compounds 9a and 9h were found to be the most cytotoxic among currently known

A Facile Synthetic Approach to Nonracemic Substituted Pyrrolo-allocolchicinoids Starting from Natural Colchicine

A six-step semisynthetic approach towards chiral nonracemic pyrrolo-allocolchicinoids starting from naturally occurring colchicine was developed. The synthetic scheme includes an electrocyclic tropolone ring contraction to afford allocolchicinic acid followed by the Curtius reaction, giving the corresponding aniline. The Sandmeyer reaction and copper-mediated hydrazination gave hydrazine-substituted allocolchicine. This was introduced into the Fischer indole synthesis, affording libraries of regioisomeric indole-based allocolchicine congeners.