38847-79-9

Upstream product

• 50653-32-2 (S)-2-((R)-Hydroxy-phenyl-methyl)-N,N-dimethyl-butyramide 
• 78175-52-7 (S)-2-((R)-Hydroxy-phenyl-methyl)-N,N-dimethyl-thiobutyramide 
• 760-79-2 N,N-dimethylbutyramide 
• 17709-96-5 N,N-dimethylbutanethioamide 
• 100-52-7 benzaldehyde 
• 50653-32-2 (S)-2-((S)-Hydroxy-phenyl-methyl)-N,N-dimethyl-butyramide 
• 78175-52-7 (S)-2-((S)-Hydroxy-phenyl-methyl)-N,N-dimethyl-thiobutyramide 

Relevant academic research and scientific papers

SUR LES ORGANOMETALLIQUES ISSUS DE THIOAMIDES. I. REACTIVITE AVEC LES ALDEHYDES ET CETONES; STEREOCHIMIE DE LA CONDENSATION AVEC LA t-BUTYL-4 CYCLOHEXANONE ET LE BENZALDEHYDE

Organometallic compounds derived from thioamides RCH2CSN(R3)2 condense normally with aldehydes and saturated ketones.Condensation with 4-t-butylcyclohexanone leads predominantly to equatorial attack by the organometallic compound.These results suggest that the organometallic structure is RCH=C(SM)N(R3)2.The stereoselectivity of the reaction with benzaldehyde depends on R and R3; a mechanism for the formation of β-hydroxythioamides is discussed.