38849-41-1Relevant academic research and scientific papers
First total synthesis of the pavine alkaloid (±)-neocaryachine and its optical resolution
Miura, Yuta,Saito, Yohei,Goto, Masuo,Nakagawa-Goto, Kyoko
, p. 899 - 902 (2020/11/26)
The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler-Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (?)-1.
Asymmetric total synthesis of (S)-isocorydine
Zhong, Mei,Jiang, Yunbin,Chen, Yali,Yan, Qian,Liu, Junxi,Di, Duolong
, p. 1145 - 1149 (2015/10/28)
The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocory
