38849-51-3

Upstream product

• 1131-94-8 homoisovanillic acid 
• 6948-30-7 5-bromoveratralaldehyde 
• 23428-79-7 2-(3-Benzyloxy-4-methoxy-phenyl)-N-[2-(3-bromo-4,5-dimethoxy-phenyl)-ethyl]-acetamide 
• 5487-33-2 O-benzylhomoisovanillic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 23495-76-3 1-(3-benzyloxy-4-methoxy-benzyl)-8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 477-57-6 tetrandrine 
• 38849-59-1 5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol 

Relevant academic research and scientific papers

Full-synthetic method of racemic tetrandrine

The invention discloses a full-synthetic method of racemic tetrandrine, and belongs to the technical field of drug synthesis. The full-synthetic method of the racemic tetrandrine comprises the steps that a synthetic route adopts a convergence synthesis method, a 5-bromovanillin, namely a compound 1 and 3-hydroxy-4-methoxyphenylacetic acid, namely a compound 5 are taken as starting materials to obtain a compound 4 and a compound 6 respectively, then the compound 4 and the compound 6 are taken as raw materials to synthesize a compound 11, a compound 19 is synthesized from the compound 11, and finally, the compound 11 reacts with the compound 19. The full-synthetic method of the racemic tetrandrine has the advantages that the synthetic efficiency is higher, the yield is higher, and the cost is lower; the reaction conditions are milder, the operation is simple and convenient, the industrial value is higher, and a reference is provided for the full-synthetic method of optical voidness tetrandrine.