3885-41-4Relevant articles and documents
Zinc-induced deoximation of α,α′-dioxo-type oximes and oxime ethers leading to α,β-diketo esters
Ryu, Ilhyong,Kuriyama, Hiroki,Miyazato, Hironari,Minakata, Satoshi,Komatsu, Mitsuo,Yoon, Joo-Yong,Kim, Sunggak
, p. 1407 - 1408 (2004)
The deoximation of a variety of α,α′-dioxo-type oximes and oxime ethers was achieved under mild conditions using zinc/AcOH, which gave good yields of α,β-diketo esters.
A convenient synthesis of pyridine and 2,2′-bipyridine derivatives
Altuna-Urquijo, Marta,Gehre, Alexander,Stanforth, Stephen P.,Tarbit, Brian
experimental part, p. 975 - 984 (2009/04/10)
α-Chloro-α-acetoxy-β-keto-esters 9 were readily prepared from β-keto-esters 6 in good overall yields. These compounds reacted as α,β-diketo-ester equivalents 2 with amidrazones 1 yielding triazines 3, generally in good yields. Picolinates 10 provided an alternative source of α,β-diketo-ester equivalents 2 when treated with copper(II) acetate. A 'one-pot' reaction of the α,β-diketo-ester equivalents 2 with amidrazones 1 in the presence of 2,5-norbornadiene 5 in boiling ethanol yielded the pyridines 4 and 2,2′-bipyridines 4 (R1=2-pyridyl) directly without the need to isolate the corresponding triazines 3. Triazine 3c reacted with the aza-dienophiles 13 and 17 affording the products 16 and 18, respectively, in good yields.
An efficient and mild synthesis of highly substituted imidazoles
Brackeen, Marcus F.,Stafford, Jeffrey A.,Feldman, Paul L.,Karanewsky, Donald S.
, p. 1635 - 1638 (2007/10/02)
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