38853-67-7

Basic information

• Product Name: Tetrahydroepiberberine, Sinactine
• Synonyms: Tetrahydroepiberberine, Sinactine;Sinactin;Tetrahydroepiberberine;dl-Tetrahydroepiberberine 〔dl-Sinactin〕
• CAS NO: 38853-67-7
• Molecular Formula: C₂₀H₂₁NO₄
• Molecular Weight: 339.38504
• Mol File: 38853-67-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 175℃ (ethanol )
• Appearance: /
• Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: Tetrahydroepiberberine, Sinactine(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydroepiberberine, Sinactine(38853-67-7)
• EPA Substance Registry System: Tetrahydroepiberberine, Sinactine(38853-67-7)

Safety Data

• Hazardous Substances Data: 38853-67-7(Hazardous Substances Data)

Usage

Uses

Tetrahydroepiberberine is an isoquinoline alkaloid displaying antioxidant and antibacterial activity.

Upstream product

• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 

Downstream Products

• 482-74-6 cryptopine 

Relevant articles and documents

Convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids

New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.