388594-31-8

Basic information

• Product Name: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI);2-Amino-4-chloro-1,3-thiazole-5-carboxaldehyde,2-BOCprotected;tert-butyl 4-chloro-5-formylthiazol-2-ylcarbamate
• CAS NO: 388594-31-8
• Molecular Formula: C₉H₁₁ClN₂O₃S
• Molecular Weight: 262.72
• Mol File: 388594-31-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)(388594-31-8)
• EPA Substance Registry System: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)(388594-31-8)

Safety Data

• Hazardous Substances Data: 388594-31-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 76874-79-8 2-amino-4-chloro-5-formyl-1,3-thiazole 

Downstream Products

• 1029052-68-3 [5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester 
• 1029052-67-2 5-[(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)hydroxymethyl]-4-chlorothiazol-2-ylcarbamic acid tert-butyl ester 

Relevant articles and documents

Tetramethylammonium Fluoride Tetrahydrate for SNAr Fluorination of 4-Chlorothiazoles at a Production Scale

This article describes the use of tetramethylammonium fluoride tetrahydrate (TMAF·4H2O) for the large-scale preparation of a challenging 4-fluorothiazole. Commercially available TMAF·4H2O was procured on a large scale and rigorously dried by distillation with isopropyl alcohol and then dimethylformamide at elevated temperature. This method of drying provided anhydrous TMAF [TMAF (anh)] containing a 45.1 kg scale at 95-100 °C to produce 36.8 kg of 4-fluorothiazole 1b.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR

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