Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 388594-31-8
• Molecular Formula: C9H11 Cl N2 O3 S
• Molecular Weight: 262.717
• Hs Code.: 2934100090
• Mol file: 388594-31-8.mol

Synonyms:Carbamicacid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 96.53000
• LogP: 3.02900

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-chloro-1,3-thiazole-5-carboxaldehyde, 2-Boc protected ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)

There total 1 articles about Carbamic acid, (4-chloro-5-formyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-4-chloro-5-formyl-1,3-thiazole (76874-79-8) → (4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester (388594-31-8)

Guidance literature:

With dmap; In 1,4-dioxane; at 60 ℃; for 2h;

DOI:10.1016/j.bmc.2004.08.050

Reference yield: 97.0%

bromo(3-fluorophenyl)magnesium (17318-03-5) + (4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester (388594-31-8) → tert-butyl 4-chloro-5-((3-fluorophenyl)(hydroxy)methyl)thiazol-2-ylcarbamate

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

Reference yield: 60.3%

1-benzenesulfonyl-5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine (1001414-09-0) + (4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester (388594-31-8) → 5-[(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)hydroxymethyl]-4-chlorothiazol-2-ylcarbamic acid tert-butyl ester (1029052-67-2)

Guidance literature:

1-benzenesulfonyl-5-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at -45 - -25 ℃; for 0.666667h; Inert atmosphere;

(4-chloro-5-formylthiazol-2-yl)carbamic acid tert-butyl ester; In tetrahydrofuran; at -65 - 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-4-chloro-5-formyl-1,3-thiazole

Downstream raw materials:

5-[(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)hydroxymethyl]-4-chlorothiazol-2-ylcarbamic acid tert-butyl ester

[5-(1-benzenesulfonyl-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-4-chlorothiazol-2-yl]carbamic acid tert-butyl ester

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