388598-00-3Relevant academic research and scientific papers
Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives
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Page 21; 22, (2008/06/13)
Novel spirobenzoazepine compounds, novel processes for the preparation of nonpeptide substituted spirobenzoazepine derivatives, and novel processes for the preparation of intermediates in the preparation of such derivatives. Novel intermediates in the preparation of nonpeptide substituted spirobenzoazepine derivatives.
Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists
Xiang, Min Amy,Chen, Robert H.,Demarest, Keith T.,Gunnet, Joseph,Look, Richard,Hageman, William,Murray, William V.,Combs, Donald W.,Rybczynski, Philip J.,Patel, Mona
, p. 3143 - 3146 (2007/10/03)
A series of substituted spirobenzazepines was prepared and evaluated as V1a and V2 dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.
