388622-16-0

Upstream product

• 213828-30-9 5-[(4-methoxyphenoxy)methyl]-5-[(phenylmethoxy)methyl]-3,4,5-trihydrofuran-2-one 
• 388621-92-9 5-methyl-3-(2-methylpropyl)hexan-1-one 
• 924657-63-6 5-benzyloxymethyl-3-(1-hydroxy-3-isobutyl-5-methyl-hexyl)-5-(4-methoxy-phenoxymethyl)-dihydro-furan-2-one 
• 100-51-6 benzyl alcohol 
• 213828-29-6 1-(benzyloxy)-2-[(4-methoxyphenoxy)methyl]-4-penten-2-ol 
• 213828-28-5 1-(benzyloxy)-3-(4-methoxyphenoxy)acetone 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 

Downstream Products

• 862549-26-6 (Z)-5-(hydroxymethyl)-5-[(4-methoxyphenoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-4,5-dihydrofuran-2-one 
• 924657-68-1 (E)-3-[4-[3-Isobutyl-5-methyl-hex-(Z)-ylidene]-2-(4-methoxy-phenoxymethyl)-5-oxo-tetrahydro-furan-2-yl]-acrylic acid tert-butyl ester 
• 568571-20-0 (Z)-N-hydroxy-2,2-dimethyl-N-({4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxo-2-[(phenylmethoxy)methyl]-(2-2,3-dihydrofuryl)}methyl)propanamide 
• 388622-20-6 (Z)-5-[(hydroxylamino)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 
• 862549-30-2 (Z)-{2-[(4-methoxyphenoxy)methyl]-4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxo-2-2,3-dihydrofuryl}methyl methylsulfonate 
• 946570-37-2 Z-{4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxo-2-[(phenylmethoxy)methyl]-2-(2,3-dihydrofuryl)}methyl 3-methylbutanoate 
• 388622-18-2 (Z)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 
• 497819-04-2 (Z)-5-(hydroxymethyl)-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 

Relevant academic research and scientific papers

Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators

DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the sn-1 position, a common feature in this template, is relevant for C1 domain interactions, but it represents a labile

Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKCδ

Diacylglycerol (DAG) lactones have provided a powerful platform for structural exploration of the interactions between ligands and the C1 domains of protein kinase C (PKC). In this study, we report that DAG-dioxolanones, novel derivatives of DAG-lactones,

Branched diacylglycerol-lactones as potent protein kinase C ligands and α-secretase activators

Using as our lead structure a potent PKC ligand (1) that we had previously described, we investigated a series of branched DAG-lactones to optimize the scaffold for PKC binding affinity and reduced lipophilicity, and we examined the potential utility of s

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

The structures of N-hydroxylamides la and lb, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. Here, we report the sy