388622-19-3

Basic information

• Product Name: (E)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one
• Synonyms: (E)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one
• CAS NO: 388622-19-3
• Molecular Weight: 386.532
• Mol File: 388622-19-3.mol

Chemical Properties

• CAS DataBase Reference: (E)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one(388622-19-3)
• EPA Substance Registry System: (E)-5-carbonyl-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one(388622-19-3)

Safety Data

• Hazardous Substances Data: 388622-19-3(Hazardous Substances Data)

Upstream product

• 388621-92-9 5-methyl-3-(2-methylpropyl)hexan-1-one 
• 213828-30-9 5-[(4-methoxyphenoxy)methyl]-5-[(phenylmethoxy)methyl]-3,4,5-trihydrofuran-2-one 
• 924657-63-6 5-benzyloxymethyl-3-(1-hydroxy-3-isobutyl-5-methyl-hexyl)-5-(4-methoxy-phenoxymethyl)-dihydro-furan-2-one 
• 388622-17-1 (E)-5-[(4-methoxyphenoxy)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 
• 497819-05-3 (E)-5-(hydroxymethyl)-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 

Downstream Products

• 388622-21-7 (E)-5-[(hydroxylamino)methyl]-3-[5-methyl-3-(2-methylpropyl)hexylidene]-5-[(phenylmethoxy)methyl]-4,5-dihydrofuran-2-one 
• 568571-24-4 (E)-N-hydroxy-2,2-dimethyl-N-({4-[5-methyl-3-(2-methylpropyl)hexylidene]-5-oxo-2-[(phenylmethoxy)methyl]-(2-2,3-dihydrofuryl)}methyl)propanamide 

Relevant articles and documents

Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain

The structures of N-hydroxylamides la and lb, previously reported by Lee et al. in J. Med. Chem. 2001, 44, 4309-4312 as strong protein kinase C (PK-C) ligands, were incorrect and correspond instead to esters 2a and 2b, respectively. Here, we report the sy

Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications

An approach to reduce the log P in a series of diacylglycerol (DAG)-lactones known for their high binding affinity for protein kinase C (PK-C) is presented. Branched alkyl groups with reduced lipophilicity were selected and combined with the replacement o