38863-02-4Relevant academic research and scientific papers
N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects
Qian, Xuhong,Yao, Wei,Chen, Gang,Huang, Xiayu,Mao, Ping
, p. 6175 - 6178 (2001)
A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.
