388631-32-1Relevant articles and documents
Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: Synthesis, reactivity, and mechanistic analysis
Meng, Xiaoli,Maggs, James L.,Pryde, David C.,Planken, Simon,Jenkins, Rosalind E.,Peakman, Torren M.,Beaumont, Kevin,Kohl, Christopher,Park, B. Kevin,Stachulski, Andrew V.
, p. 6165 - 6176 (2007)
The neutral endopeptidase inhibitor (2R)-2-[(1-{[(5-ethyl-1,3,4-thiadiazol- 2-yl)amino]carbonyl}cyclopentyl)-methyl]pentanoic acid 2 is metabolized to acyl glucuronide 3. Unprecedentedly, at pH 7.4, 3 does not undergo the O-acyl migration characteristic o