3887-13-6

Basic information

• Product Name: GLY-GLY-GLY-GLY-GLY-GLY
• Synonyms: HEXAGLYCINE;2-[[2-[[2-[[2-[[2-(glycylamino)acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid;2-[[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid;2-[2-[2-[2-[2-(2-azanylethanoylamino)ethanoylamino]ethanoylamino]ethanoylamino]ethanoylamino]ethanoic acid;Gly6;H-GLY-GLY-GLY-GLY-GLY-GLY-OH;GLY-GLY-GLY-GLY-GLY-GLY
• CAS NO: 3887-13-6
• Molecular Formula: C₁₂H₂₀N₆O₇
• Molecular Weight: 360.32
• Mol File: 3887-13-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 492.37°C (rough estimate)
• Flash Point: 600.3 °C
• Appearance: white to off-white powder
• Density: 1.3138 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7000 (estimate)
• Storage Temp.: −20°C
• CAS DataBase Reference: GLY-GLY-GLY-GLY-GLY-GLY(CAS DataBase Reference)
• NIST Chemistry Reference: GLY-GLY-GLY-GLY-GLY-GLY(3887-13-6)
• EPA Substance Registry System: GLY-GLY-GLY-GLY-GLY-GLY(3887-13-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3887-13-6(Hazardous Substances Data)

Usage

Uses

Hexaglycine and capped hexaglycine are used in physicochemical studies of peptide structure dynamics. Hexaglycine is used as a model compound in development of peptide quantitation and separation methods.

InChI:InChI=1/C12H20N6O7/c13-1-7(19)14-2-8(20)15-3-9(21)16-4-10(22)17-5-11(23)18-6-12(24)25/h1-6,13H2,(H,14,19)(H,15,20)(H,16,21)(H,17,22)(H,18,23)(H,24,25)

Upstream product

• 556-33-2 glycine-glycine-glycine 
• 556-50-3 glycylglycine 
• 56-40-6 glycine 
• 106-57-0 Glycine anhydride 

Downstream Products

• 556-50-3 glycylglycine 
• 56-40-6 glycine 

Relevant articles and documents

Mechanochemical Prebiotic Peptide Bond Formation**

The presence of amino acids on the prebiotic Earth, either stemming from endogenous chemical routes or delivered by meteorites, is consensually accepted. Prebiotically plausible pathways to peptides from inactivated amino acids are still unclear as most oligomerization approaches rely on thermodynamically disfavored reactions in solution. Now, a combination of prebiotically plausible minerals and mechanochemical activation enables the oligomerization of glycine at ambient temperature in the absence of water. Raising the reaction temperature increases the degree of oligomerization concomitantly with the formation of a commonly unwanted cyclic glycine dimer (DKP). However, DKP is a productive intermediate in the mechanochemical oligomerization of glycine. The findings of this research show that mechanochemical peptide bond formation is a dynamic process that provides alternative routes towards oligopeptides and establishes new synthetic approaches for prebiotic chemistry.