38873-55-1

Usage

Uses

nti-inflammatory.

InChI:InChI=1/C16H12O4/c17-13(6-8-16(18)19)10-5-7-15-12(9-10)11-3-1-2-4-14(11)20-15/h1-5,7,9H,6,8H2,(H,18,19)

Upstream product

• 108-30-5 succinic acid anhydride 
• 132-64-9 dibenzofuran 
• 36109-81-6 γ-oxo-2-dibenzofuranbutanoic acid methyl ester 

Downstream Products

• 185672-77-9 4-Dibenzofuran-2-yl-4-hydroximino-butyric acid 

Relevant academic research and scientific papers

Tricyclic inhibitor of matrix metalloproteinases

A tricyclic compound is described as well as pharmaceutical compositions of same, which is useful as an inhibitor of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) for the treatment of multiple sclerosis or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.

Purification of γ-oxo-2-dibenzofuranbutyric acid

A process for the separation of γ-oxo-2-dibenzofuranbutyric acid from a mixture of said acid and γ-oxo-3-dibenzofuranbutyric acid is disclosed. Such a mixture is obtained by the prior art method of preparing γ-oxo-2-dibenzofuranbutyric acid from dibenzofuran and succinic anhydride in a Friedel-Crafts reaction. The mixture of acids is converted to a mixture of their corresponding lower alkyl esters which is separated by recrystallization or chromatography into its component alkyl esters. Hydrolysis of the lower alkyl ester of γ-oxo-2-dibenzofuranbutyric acid gives the desired corresponding acid.