38879-47-9

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 543-24-8 N-acetylglycine 
• 24474-93-9 2-methyl-4H-oxazol-5-one 

Downstream Products

• 139597-09-4 N-{4-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 138973-24-7 1,4-Bis(5'-(3,4-dimethoxybenzylidene)-2'-methyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 72053-04-4 methyl 2-acetylamino-3-(3,4-dimethoxyphenyl)-2-propenoate 
• 32255-79-1 2-hydroxy-3-(3,4-dimethoxyphenyl)propanoic acid 
• 76313-28-5 2-acetylamino-3-(3,4-dimethoxy-1-phenyl)-2-propenoic acid 
• 172895-15-7 LY 272015 
• 143815-52-5 (Z)-3-(3,4-Dimethoxy-phenyl)-2-hydroxy-acrylic acid 
• 848150-55-0 (Z)-2-acetylamino-3-(3,4-dimethoxyphenyl)-N-methyl-2-propenamide 
• 1273258-61-9 1,4:3,6-dianhydro-2,5-bis-[2-acetamido-(Z)-3,4-dimethoxycinnamamido]-2,5-dideoxy-L-iditol 
• 870258-79-0 (R)-methyl 2-acetamido-3-(3,4-dimethoxyphenyl)propanoate 
• 78148-21-7 methyl (S)-2-acetamido-3-(3,4-dimethoxyphenyl)propanoate 
• 2460-33-5 3,4-dimethoxyphenylpyruvic acid 

Relevant academic research and scientific papers

Use of azalactones in a 'Pictet-Spengler-like' reaction. Stereoselective synthesis of 1,3,4-substituted tetrahydro-β-carbolines

A 'Pictet-Spengler-like' reaction between azalactones 1 and conformationally constrained tryptamines 4 in refluxing 1N HCl over 72 h. gave the corresponding tetrahydro-β-carbolines 3 in moderate to good yields. The observed equatorial orientation of the C-1 substituent in the THBC's results from a combination of the thermal reaction conditions and conformational constraints imposed by the starting tryptamines.

New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof

PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

Pseudo-peptides derived from isomannide: Inhibitors of serine proteases

In this paper, we describe the synthesis of a novel class of pseudo-peptides derived from isomannide and several oxazolones as potential inhibitors of serine proteases as well as preliminary pharmacological assays for hepatitis C. Hepatitis C, dengue and West Nile fever are among the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes and are a primary target in the drug development field. Several pseudo-peptides were obtained in good yields from the reaction of isomannide and oxazolones, and their anti-HCV potential using the HCV replicon-based assay was shown.

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor

A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.

Electron transfer-initiated and highly selective photocyclization of N-acyl-α-dehydroarylalaninamides to 3,4-dihydroquinolinone derivatives

The irradiation of (Z)-N-acyl-α-dehydroarylalaninamides [(Z)-1] in methanol containing 1,8-diazabicyclo[5.4.0]undec-7-ene gave substituted 3,4-dihydro-2-quinolinones (2) in high yields along with minor amounts of 2-quinolinone (3) and 4,5-dihydrooxazole (

A Facile Preparation of 4-Arylidene-4,5dihydrooxazol-5-ones using Zeolite as a Cyclodehydrating Agent

An efficient new method for the azlactonisation of acylamino acids using zeolite under mild conditions is described; the method is fairly general as well as providing high yields.

Chemocontrolled reduction of aromatic α-ketoesters by NaBH4: Selective synthesis of α-hydroxy esters or 1,2-diols

α-Hydroxyesters 5a-g or diols 6a-g have been obtained in high yields by reduction of aromatic α-ketoesters 4 once or twice respectively by using NaBH4 as the reducer under suitable conditions. The use of a solvent that does not interact with the reagent allowed the double reduction to occur with only a slight excess of borohydride in very mild conditions.

Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5HT(2B)) contractile receptor in the rat stomach fundus

A series of potent, selective 5HT(2B) receptor antagonists has been identified based upon yohimbine, with SAR studies resulting in a 1000-fold increase in 5HT(2B) receptor affinity relative to the starting structure (- log K(B)s > 10.0 have been obtained). These high-affinity tetrahydro-β- carboline antagonists are able to discriminate among the 5HT2 family of serotonin receptors, with members of the series showing selectivities of more than 100-fold versus both the 5HT(2A) and 5HT(2C) receptors based upon radioligand binding and functional assays. As the first compounds reported with such selectivity and enhanced receptor affinity, these tetrahydro-β- carboline antagonists are useful tools for elucidating the role of serotonin acting at the 5HT(2B) receptor in normal and disease physiology.