38879-47-9

Basic information

• Product Name: 5(4H)-Oxazolone, 4-[(3,4-dimethoxyphenyl)methylene]-2-methyl-, (4Z)-
• CAS NO: 38879-47-9
• Molecular Formula: C13H13NO4
• Molecular Weight: 247.251
• Mol File: 38879-47-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-[(3,4-dimethoxyphenyl)methylene]-2-methyl-, (4Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-[(3,4-dimethoxyphenyl)methylene]-2-methyl-, (4Z)-(38879-47-9)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-[(3,4-dimethoxyphenyl)methylene]-2-methyl-, (4Z)-(38879-47-9)

Safety Data

• Hazardous Substances Data: 38879-47-9(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 543-24-8 N-acetylglycine 
• 24474-93-9 2-methyl-4H-oxazol-5-one 

Downstream Products

• 139597-09-4 N-{4-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-2-methyl-5-oxo-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 138973-24-7 1,4-Bis(5'-(3,4-dimethoxybenzylidene)-2'-methyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 172895-15-7 LY 272015 
• 108984-87-8 6-chloro-1-(3,4-dimethoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline 

Relevant articles and documents

Use of azalactones in a 'Pictet-Spengler-like' reaction. Stereoselective synthesis of 1,3,4-substituted tetrahydro-β-carbolines

A 'Pictet-Spengler-like' reaction between azalactones 1 and conformationally constrained tryptamines 4 in refluxing 1N HCl over 72 h. gave the corresponding tetrahydro-β-carbolines 3 in moderate to good yields. The observed equatorial orientation of the C-1 substituent in the THBC's results from a combination of the thermal reaction conditions and conformational constraints imposed by the starting tryptamines.

NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR

Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor

A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.