38894-81-4Relevant academic research and scientific papers
Practical synthesis of ε-carotene
Wu, Chunlei,Cao, Ruiwei,Song, Xiaohua,Lv, Chunlei,Ye, Weidong,Pi, Shiqing,Chen, Chaohui,Shen, Runpu
, p. 481 - 484 (2015/02/19)
A novel route for the total synthesis of ε-carotene is described. The synthesis is based on a condensation between α-cyclocitral and diethyl [(2E)-3-methoxy-2-methylprop-2-en-1-yl]phosphonate to give a C14 enol ether, hydrolysis of the C14-enol ether to a give a C14 aldehyde, and a modified Wittig-Horner reaction of the C15 phosphonate from the C14 aldehyde and a C10 triene dialdehyde to give ε-carotene. The synthetic steps are easily performed and are practical for large-scale production.
