38896-06-9Relevant articles and documents
FERROPTOSIS INHIBITORS–DIARYLAMINE PARA-ACETAMIDES
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Paragraph 0949-0950, (2021/09/11)
Provided are compounds that inhibit ferroptosis activity, or modulate or inhibit a disease associated with ferroptosis dysregulation, such as neuropathy, ischemia reperfusion injury, acute kidney failure and cancer, including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
Transition-State Polarization in Cleavage of C-C Bonds in Radical Anions
Maslak, Przemyslaw,Narvaez, Javier N.,Kula, Jozef,Malinski, David S.
, p. 4550 - 4559 (2007/10/02)
The substituent effect on the rate of C-C bond cleavage in radical anions of 1-(4-nitrophenyl)-2-(substituted-phenyl)-1,1,2,2-tetraethylethanes has been explored.The data provide evidence for two distinctive modes of bond scission.One mode is characterized by a significant negative charge transfer across the scissile bond in the transition state.Such polarization of the transition state is in contradiction to the prediction based on the fragments' stability.The second mode, dominant in cases where the charge shift leads to negative charge accumulation on an already electron-rich fragment, involves a ?* radical anion.Both modes point to a general kinetic preference for a cleavage of radical anions that allows for charge delocalization across the scissile bond.