38897-26-6

Upstream product

• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 73547-42-9 5-carbamoylbenzene-1,2,3-triyl triacetate 
• 618-73-5 3,4,5-trihydroxybenzamide 

Downstream Products

• 199531-82-3 3,4,5-tri(n-dodecyloxy)benzonitrile 
• 95933-74-7 N',3,4,5-tetrahydroxybenzenecarboximidamide 

Relevant academic research and scientific papers

Development and structure-activity relationship study of SHP2 inhibitor containing 3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulene

SHP2, a non-receptor protein tyrosine phosphatase encoded by PTPN11 gene, plays an important role in the cell growth and proliferation. Activating mutations of SHP2 have been reported as a cause of various human diseases such as solid tumors, leukemia, and Noonan syndrome. The discovery of SHP2 inhibitor can be a potent candidate for the treatment of cancers and SHP2 related human diseases. Several reports on a small molecule targeting SHP2 have published, however, there are limitations on the discovery of SHP2 phosphatase inhibitors due to the polar catalytic site environment. Allosteric inhibitor can be an alternative to catalytic site inhibitors. 3,4,6-Trihydroxy-5-oxo-5H-benzo[7]annulene 1 was obtained as an initial hit with a 0.097 μM of IC50 from high-throughput screening (HTS) study. After the structure-activity relationship (SAR) study, compound 1 still showed the most potent activity against SHP2. Moreover, compound 1 exerted good potency against SHP2 expressing 2D and 3D MDA-MB-468.

Room-temperature discotic liquid-crystalline coronene diimides exhibiting high charge-carrier mobility in air

Six N,N′,5,11-tetrasubstituted coronene-2,3,8,9-tetracarboxydiimides have been synthesised incorporating 3,4,5-tri(n-dodecyloxy)phenyl or 2-(n-decyl)-n-tetradecyl groups in various positions. Differential scanning calorimetry, polarised optical microscopy, and X-ray diffraction indicate that all form columnar discotic mesophases from around room temperature to around 200 °C. Charge-carrier mobility values, which energetic considerations suggest are electron mobility values, have been determined in non-aligned samples cooled from the isotropic melt using the space-charge-limited current technique. The highest mobility, 6.7 cm2 V-1 s-1, was found in N,N′-bis(n-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecylfluorooctyl)-5,11- bis(3-[{3,4,5-tri(n-dodecyloxy)phenyl}carbonyloxy]-n-propyl)coronene-2,3,8, 9-tetracarboxydiimide, which X-ray diffraction suggests is the most highly ordered of the materials examined.

Perylene Charge-Transport Materials, Methods of Fabrication Thereof, and Methods of Use Thereof

Briefly described, embodiments of this disclosure include perylenetetracarboxylic diimide charge-transport materials, methods of forming perylenetetracarboxylic diimide charge-transport materials, and methods of using the perylenetetracarboxylic diimide charge-transport materials.

Polyhydroxybenzoic acid derivatives

Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.

Polyhydroxybenzoic acid derivatives

Polyhydroxy-substituted benz, phenylacet and mandelamidines, amidates, amidoximes and hydroxyamidoximes--ribonucleotide reductase inhibitors, and free radical scavengers.