95933-74-7 Usage
Description
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM.
Uses
Trimidox is a specific ribonucleotide reductase inhibitor.
references
[1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123.
Check Digit Verification of cas no
The CAS Registry Mumber 95933-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,9,3 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 95933-74:
(7*9)+(6*5)+(5*9)+(4*3)+(3*3)+(2*7)+(1*4)=177
177 % 10 = 7
So 95933-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O4/c8-7(9-13)3-1-4(10)6(12)5(11)2-3/h1-2,9-11,13H,8H2
95933-74-7Relevant articles and documents
Methods for treating or preventing neuroinflammation or autoimmune diseases
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Page/Page column 22, (2017/01/19)
Disclosed herein are ribonucleotide reductase inhibitors, compositions comprising ribonucleotide reductase inhibitors, and methods for treating and/or preventing autoimmune diseases and neuroinflammatory diseases with the ribonucleotide reductase inhibitors.
