3890-98-0

Basic information

• Product Name: Ethanol, 2-[(2-chloroethyl)amino]-
• CAS NO: 3890-98-0
• Molecular Formula: C4H10ClNO
• Molecular Weight: 123.582
• Mol File: 3890-98-0.mol

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-[(2-chloroethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-[(2-chloroethyl)amino]-(3890-98-0)
• EPA Substance Registry System: Ethanol, 2-[(2-chloroethyl)amino]-(3890-98-0)

Safety Data

• Hazardous Substances Data: 3890-98-0(Hazardous Substances Data)

Usage

Uses

Used in Industrial Applications:
Ethanol, 2-[(2-chloroethyl)amino]is used as a corrosion inhibitor to protect metal surfaces from corrosion, as an emulsifier to stabilize mixtures of immiscible liquids, and as a surfactant to reduce surface tension between liquids and solids.
Used in Detergent Production:
In the detergent industry, ethanol, 2-[(2-chloroethyl)amino]is used as a component to enhance the cleaning properties of detergents, providing better dispersion of dirt and grease.
Used in Cosmetics and Personal Care Products:
Ethanol, 2-[(2-chloroethyl)amino]is utilized in the formulation of cosmetics and personal care products for its emulsifying and surfactant properties, which contribute to the stability and effectiveness of these products.
However, it is important to note that ethanol, 2-[(2-chloroethyl)amino]is considered a skin and eye irritant, and can be harmful if ingested or inhaled in large quantities. Therefore, proper handling and safety precautions are essential when working with this chemical to ensure the well-being of individuals and the environment.

Upstream product

• 100129-68-8 1-benzoyloxy-2-(2-chloro-ethylamino)-ethane; hydrochloride 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 1566-15-0 N,N-bis(2-chloroethyl)phosphorodiamidic acid cyclohexylammonium salt 

Downstream Products

• 944088-69-1 2-[(2-chloroethyl)(2-hydroxyethyl)amino]-3,5-dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide 

Relevant articles and documents

Kinetics of phosphoramide mustard hydrolysis in aqueous solution

Hydrolysis of phosphoramide mustard was investigated using HPLC, 31P NMR, and GC-MS with specific deuterium labels. The hydrolysis of phosphoramide mustard in sodium phosphate buffers was found to follow apparent first-order kinetics. The rate of hydrolysis was temperature and pH dependent, being slower under acidic conditions. The hydrolysis was not catalyzed by hydroxyl ion, and its pH dependence appeared to be the result of a change in the mechanism of hydrolysis at different pH values. At a pH value approximately above the pK(a) of the phosphoramide mustard nitrogen, the major hydrolytic pathway of phosphoramide mustard was via the formation of the aziridinium ion, followed by nucleophilic attack. At pH values below its pK(a), cleavage of the P-N bond predominated. At pH 7.4, the formation of an aziridinium ion was followed by a rapid hydrolysis to yield the monohydroxy and, subsequently, the dihydroxy products. The hydrolysis at this pH was adequately described by consecutive first-order kinetics. Seven species in the hydrolytic mixture have been identified as intact phosphoramide mustard, N-(2-chloroethyl)-N-(2-hydroxyethyl)phosphorodiamidic acid, N,N-bis-(2-hydroxyethyl)phosphorodiamidic acid, phosphoramidic acid, phosphoric acid, N,N-bis-(2-chlorethyl)amine, and N-(2-chloroethyl)-N-(2-hydroxyethyl)amine by GC-MS with the aid of deuterium labels. Phosphoramide mustard was found to be stabilized by chloride ion. The stabilization was linearly related to the chloride ion concentration, and the mechanism was found to be via the formation of phosphoramide mustard from the aziridinium and chloride ions. Phosphoramide mustard was significantly more stable in human plasma and in 5% human serum albumin as compared to aqueous buffers, an observation that may be important in vivo.