389065-64-9

Upstream product

• 7177-79-9 methyl 2,3-O-dibenzyl-4,6-O-benzylidene-α-D-glucopyranoside 
• 17791-36-5 methyl 2,3-di-O-benzyl-α-D-glucopyranoside 
• 3162-96-7 4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 54522-57-5 methyl-2,3-di-O-benzyl-6-O-(4-toluenesulfonyl)-α-D-glucopyranoside 
• 54522-58-6 methyl 6-azido-2,3-di-O-benzyl-6-deoxy-α-D-glucopyranoside 

Downstream Products

• 674782-48-0 methyl 4,6-diazido-2,3-di-O-benzyl-4,6-dideoxy-α-D-glucopyranoside 
• 242148-41-0 methyl 6-azido-2,3-di-O-benzyl-6-deoxy-α-D-galactopyranoside 

Relevant academic research and scientific papers

Studies of the stereoselective reduction of ketosugar (hexosulose)

The results from the studies of the stereoselective reduction of ketosugar (hexosulose) were reported. Combining our results and those reported in the literature, we summarize the factors in controlling the stereoselective reduction of ketosugars. These findings are valuable in the synthesis of various carbohydrate derivatives.

Application of the Synthetic Aminosugars for Glycodiversification: Synthesis and Antimicrobial Studies of Pyranmycin

A divergent approach was employed for the synthesis of aminosugars, from which a novel library of aminoglycoside antibiotics (pyranmycins) was synthesized. Pyranmycins have comparable antibacterial activity as neomycin, a clinically used aminoglycoside antibiotic, against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Mycobacterium smegmatis. In addition, pyranmycins, like streptomycin, are bacteriocidal while isoniazid (INH) is bacteriostatic. Therefore, pyranmycins may provide new therapeutic options in the treatment against tuberculosis. Several members of pyranmycins also manifest modest anti-Tat and anti-Rev activities, which may aid in the development of new anti-HIV agents. Although the antibacterial activity of pyranmycins against aminoglycoside resistant bacteria is less than expected, the synthetic methodologies of utilizing a library of aminosugars can be a model for future studies of glycodiversification or glycorandomization.