389130-06-7 Usage
Uses
Used in Chemical Synthesis:
(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE is used as a chiral ligand in the Cu-catalyzed synthesis of chiral 3-(arylbut-1-yn-1-yl)silane derivatives. This application is significant because it allows for the creation of chiral molecules, which are essential in the pharmaceutical industry for developing drugs with specific biological activities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE is used as a chiral ligand for the Rh-catalyzed asymmetric hydrogenation of R-isopropylcinnamic acid derivative. This process is crucial for the production of a key intermediate of the renin inhibitor aliskiren, which is an important drug for treating hypertension.
Used in Catalyst Development:
(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE is also used as a chiral ligand in the Rh-catalyzed conjugate addition of arylboronic acids to lactones, enones, and nitroalkenes. This application is vital for the development of new catalysts and the synthesis of various complex organic molecules, which can be used in the production of pharmaceuticals, agrochemicals, and other specialty chemicals.
Reaction
A ligand for enantioselective hydrogenation of prochiral functional olefins.
Check Digit Verification of cas no
The CAS Registry Mumber 389130-06-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,9,1,3 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 389130-06:
(8*3)+(7*8)+(6*9)+(5*1)+(4*3)+(3*0)+(2*0)+(1*6)=157
157 % 10 = 7
So 389130-06-7 is a valid CAS Registry Number.
389130-06-7Relevant academic research and scientific papers
Influence of phosphoramidites in copper-catalyzed conjugate borylation reaction
Sole, Cristina,Bonet, Amadeu,De Vries, Andre H. M.,De Vries, Johannes G.,Lefort, Laurent,Gulyas, Henrik,Fernandez, Elena
, p. 7855 - 7861 (2013/01/16)
Copper(I) has become the preferred metal to catalyze the β-boration of α,β-unsaturated carbonyl compounds, and now we demonstrate that easily accessible monodentate chiral ligands, such as phosphoramidites and phosphites, can be convenient alternative ligands to induce asymmetry in the enantioselective version of this reaction, particularly in the β-boration of α,β-unsaturated imines.
