389142-40-9

Upstream product

• 111-42-2 2,2'-iminobis[ethanol] 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 389142-43-2 N,N-bis-(2-diethylcarbamoyloxyethyl)-N-p-nitrobenzenesulfonamide 
• 952-97-6 4-nitrophenyl phenyl sulfide 
• 1246807-83-9 4-(2-(4-(4-nitrophenylsulfonyl)piperazine-1-yl)phenyl)morpholine 
• 1246807-80-6 1-(2-tert-butylphenyl)-4-(4-nitrophenylsulfonyl)piperazine 
• 1582306-23-7 N,N-bis[(benzimidazol-1-yl)ethyl]-4-nitrobenzenesulfonamide 
• 1582306-26-0 N,N-bis[(imidazol-1-yl)ethyl]-4-nitrobenzenesulfonamide 
• 346691-54-1 1-[(4-nitrobenzene)sulfonyl]-4-phenylpiperazine 

Relevant academic research and scientific papers

Piptides: New, Easily Accessible Chemotypes For Interactions With Biomolecules

Small molecule probe development is pivotal in biomolecular science. Research described here was undertaken to develop a non-peptidic chemotype, piptides, that is amenable to convenient, iterative solid-phase syntheses, and useful in biomolecular probe discovery. Piptides can be made from readily accessible pip acid building blocks and have good proteolytic and pH stabilities. An illustrative application of piptides against a protein-protein interaction (PPI) target was explored. The Exploring Key Orientations (EKO) strategy was used to evaluate piptide candidates for this. A library of only 14 piptides contained five members that disrupted epidermal growth factor (EGF) and its receptor, EGFR, at low micromolar concentrations. These piptides also caused apoptotic cell death, and antagonized EGF-induced phosphorylation of intracellular tyrosine residues in EGFR.

HETEROCYCLIC COMPOUND USED AS FGFR INHIBITOR

A heterocyclic compound is described, which is an inhibitor of FGFR (fibroblast growth factor receptor). Specifically, it is a compound represented by the following formula (I), including an isomer (enantiomer or diastereomer) which may be present, or a p

Synthesis and antibacterial evaluation of some novel imidazole and benzimidazole sulfonamides

Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by 1H-NMR, 13C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against stan

Investigation of macrocyclisation routes to 1,4,7-triazacyclononanes: Efficient syntheses from 1,2-ditosylamides

Two routes to the synthesis of a cyclohexyl-fused 1,4,7-triazacyclononane involving macrocyclisations of tosamides have been investigated. In the first approach, using a classic Richman-Atkins-type cyclisation of a cyclohexyl-substituted 1,4,7-tritosamide

Fluorescent sensors for the enantioselective recognition of mandelic acid: Signal amplification by dendritic branching

Novel chiral bisbinaphthyl compounds have been synthesized for the enantioselective fluorescent recognition of mandelic acid. By introducing dendritic branches to the chiral receptor unit, the fluorescence signals of the receptors are significantly amplif