3893-40-1

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 103-79-7 1-phenyl-acetone 
• 127-65-1 chloroamine-T 
• 172613-65-9 N-(2-oxo-1-phenyl-1-propyl)-carbamic acid tert-butyl ester 
• 155396-71-7 tert-butyl N-(phenyl(phenylsulfonyl)methyl)carbamate 
• 98-59-9 p-toluenesulfonyl chloride 
• 58567-43-4 4-methyl-N-(1-phenyl-allyl)-benzenesulfonamide 
• 137595-21-2 N-(p-tolylsulfonyl)-2-methyl-3-phenylaziridine 

Downstream Products

• 127598-11-2 4-methyl-N-(2-methyl-1-phenylallyl)benzenesulfonamide 
• 58107-42-9 trans-2-Hydroxy-1-phenyl-1-tosylaminopropan 
• 127598-01-0 N-((1S*,2S*)-3-hydroxy-2-methyl-1-phenylpropyl)-4-methylbenzenesulfonamide 
• 127598-01-0 N-[3-hydroxy-2-methyl-1-phenylpropyl]-4-methylbenzenesulfonamide 
• 127598-01-0 N-((R)-3-Hydroxy-2-methyl-1-phenyl-propyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Catalyst-controlled Wacker-type oxidation of protected allylic amines

On the contrary: Utilizing the [Pd-(quinox)]-TBHP catalyst system, protected allylic amines were oxidized with high selectivity for the methyl ketone product. This is contrary to the results obtained by the substrate-controlled Tsuji-Wacker oxidation, which highlights the catalyst-controlled system presented here (see scheme). A variety of N-pro-tecting groups undergo selective oxidation with high ketone selectivity. TBHP = tert-butylhydroperoxide.

Aldehyde selective Wacker oxidations of phthalimide protected allylic amines: A new catalytic route to β3-amino acids

(Chemical Equation Presented) A new method for the synthesis of β3-amino acids is presented. Phthalimide protected allylic amines are oxidized under Wacker conditions selectively to aldehydes using PdCl2 and CuCl or Pd(MeCN)2/s

Facile preparation of α-amino ketones from oxidative ring-opening of aziridines by pyridine N-oxide

The oxidative ring-opening reaction of a variety of activated aziridines by pyridine N-oxide provided α-amino ketones or α-amino aldehydes in good yields. The Royal Society of Chemistry.

Sulfamidation of 2-arylaldehydes and ketones with chloramine-T

A series of aliphatic and aromatic carbonyl compounds has been transformed into the corresponding sulfamidated products by means of amine-catalyzed nitrene transfer of chloramine-T. Depending on the residues R, either α-sulfamidation in the case of aromat