38938-52-2

Upstream product

• 134-85-0 4-chlorobenzophenone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 81-07-2 saccharin 
• 38938-57-7 3-(4-chlorophenyl)-2,3-dihydrobenzo[d]isothiazole–1,1-dioxide 

Downstream Products

• 1365284-38-3 C₂₀H₁₆ClNO₂S 
• 1418635-27-4 C₂₀H₁₆ClNO₂S 

Relevant academic research and scientific papers

Efficient visible-light photocatalytic aerobic oxidation of cyclic sulfamides to imines

A highly efficient photocatalytic aerobic oxidation of cyclic sulfamides to synthesize cyclic N-sulfonyl imines with Ir(ppy)2(dtbpy)PF6 as photocatalyst is reported. These environmentally friendly transformations exihibit good to excellent isolated yields and good generality with respect to both five-membered and six-membered cyclic sulfamides.

B(C6F5)3-Catalyzed Reduction of Cyclic N-Sulfonyl Ketimines

A metal-free method for reduction of cyclic N-sulfonyl ketimines catalyzed by B(C6F5)3, using commercially available methylphenylsilane as a reducing reagent under mild conditions has been developed. This reductive protoco

Iridium(III)-Catalyzed Selective and Mild C-H Amidation of Cyclic N-Sulfonyl Ketimines with Organic Azides

A general protocol for iridium catalyzed direct C?H amidation of cyclic N-sulfonyl ketimines using sulfonyl, acyl and aryl azides as nitrogen source is reported herein. The reaction takes place at room temperature with acyl and aryl azides, while an elevated temperature needed with sulfonyl azides to furnish aminated sultams in excellent yields with complete chemo and regioselectivity, thus providing a robust and environmentally benign process to the synthesis of aminosultams. (Figure presented.).

Rh(III)-catalyzed diastereodivergent spiroannulation of cyclic imines with activated alkenes

Rh(III)-catalyzed [3 + 2] annulation of cyclic N-sulfonyl or N-acyl ketimines with activated alkenes has been realized, leading to the synthesis of spirocycles with three continuous stereogenic centers. This atom-economic reaction proceeded efficiently under mild and redox-neutral conditions via a C-H activation pathway, and the coupling is diastereodivergent, with the diastereoselectivity being controlled by silver additives.

REACTION OF CHLOROSULFONYL ISOCYANATE WITH BENZOPINACOLONES AND BENZOPHENONES: SYNTHESIS OF BENZOPINACOLONE-2'-SULFONAMIDES AND BENZOISOTHIAZOLE-1,1-DIOXIDES

Benzopinacolones, 1a-c, reacted with chlorosulfonyl isocyanate (CSI) at 130 deg C to yield the benzopinacolone-2'-sulfonamides, 4a-c.Similarly benzophenones, 5a-d, reacted with CSI to give the benzoisothiazole-1,1-dioxides, 7a-d.