38938-54-4

Upstream product

• 38938-59-9 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 81-07-2 saccharin 
• 64939-35-1 2-(4-methyl-benzoyl)-benzenesulfonic acid; ammonium salt 
• 64939-36-2 2-(4-methyl-benzoyl)-benzenesulfonyl chloride 

Downstream Products

• 1609405-66-4 (E)-methyl 3-(2-(1,1-dioxidobenzo[d]isothiazol-3-yl)-5-methylphenyl)acrylate 
• 1568952-26-0 5′-methyl-2′,3′-diphenyl-2H-spiro[benzo[d]isothiazole-3,1′-indene]1,1-dioxide 
• 1365284-30-5 C₂₁H₁₉NO₂S 
• 1365284-28-1 (S)-3-phenyl-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide 
• 1356266-11-9 (E)-ethyl 2-(4,4-dioxido-8b-(p-tolyl)-1H-azeto[1,2-b]benzo[d]isothiazol-2(8bH)-ylidene)acetate 
• 1356266-24-4 ethyl 9b-(p-tolyl)-3,9b-dihydrobenzo[d]pyrrolo[1,2-b]isothiazole-1-carboxylate 5,5-dioxide 
• 1166859-71-7 (S)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole-1,1-dioxide 
• 1259436-57-1 (R)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide 
• 38938-59-9 3-(4-methylphenyl)-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide 

Relevant academic research and scientific papers

Efficient visible-light photocatalytic aerobic oxidation of cyclic sulfamides to imines

A highly efficient photocatalytic aerobic oxidation of cyclic sulfamides to synthesize cyclic N-sulfonyl imines with Ir(ppy)2(dtbpy)PF6 as photocatalyst is reported. These environmentally friendly transformations exihibit good to excellent isolated yields and good generality with respect to both five-membered and six-membered cyclic sulfamides.

Pd/Zn(OTf)2 Co-Catalyzed Asymmetric Hydrogenation of Imines under Normal Pressure of Hydrogen

An efficient method for the asymmetric hydrogenation of cyclic and acyclic N-sulfonylimines co-catalyzed by Pd/Zn(OTf)2 using hydrogen gas under ambient pressure was developed. The methodology offers an easy access to generate chiral sulfonylam

Iridium(III)-Catalyzed Selective and Mild C-H Amidation of Cyclic N-Sulfonyl Ketimines with Organic Azides

A general protocol for iridium catalyzed direct C?H amidation of cyclic N-sulfonyl ketimines using sulfonyl, acyl and aryl azides as nitrogen source is reported herein. The reaction takes place at room temperature with acyl and aryl azides, while an elevated temperature needed with sulfonyl azides to furnish aminated sultams in excellent yields with complete chemo and regioselectivity, thus providing a robust and environmentally benign process to the synthesis of aminosultams. (Figure presented.).

Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines

Benzylic N-substituted stereocenters constitute a frequent structural motif in drugs. Their highly enantioselective generation is hence of technical importance. An attractive strategy is the arylation of imines with organoboron reagents. Chiral Rh complexes have reached a high level of productivity for this reaction type. In this article we describe that an electron rich PdIIcatalyst also performs well in the arylation of aldimines, comparable to the best Rh catalysts. The ferrocenyl palladacycle-acetate catalyst allows for a broad substrate scope and very high enantioselectivities. Commonly observed side reactions like aryl–aryl homocouplings and imine hydrolysis could be blocked. Mechanistic studies implicate that a) the acetate ligand is crucial for transmetallation, b) the active catalyst is most likely a palladacycle-OAc monomer, c) the rate limiting step is probably the product release. By added KOAc the arylation could also be applied to ketimines.

Formal palladium-catalyzed asymmetric hydrogenolysis of racemic N -sulfonyloxaziridines

Highly enantioselective palladium-catalyzed formal hydrogenolysis of racemic N-sulfonyloxaziridines has been realized, providing a novel access to sultams with up to 99% ee. Preliminary mechanistic insights revealed that the reaction proceeded through a N-O bond cleavage, dehydration, and the sequential asymmetric hydrogenation.

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors

3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). Thus, the structure-activity relationships of benzo[1.3.2]dithiazolium ylide 1,1-dioxide skeleton were carried out. The 6-NO2 group played an essential role in the inhibitory activity. In addition, moderate-sized lipophilic substituents at the para-position of the 3-aryl moiety were required for dual COX-2/5-LOX inhibitory activity. Among the identified potent dual inhibitors, 3-(4-tbutylphenyl) derivative 30c (IC50 values of 0.27 μM and 0.30 μM against COX-2 and 5-LOX, respectively) and 3-(4-biphenyl) derivative 30f (IC50 values of 0.50 μMand 0.15 μMagainst COX-2 and 5-LOX, respectively) were the most potent dual COX-2/ 5-LOX inhibitors. Intraperitoneal administration of 30c at 100 mg/kg demonstrated potent acute antiinflammatory activity. As a result, benzo[1.3.2]dithiazolium ylide 1,1-dioxide represented a novel scaffold for the exploitation in developing dual COX-2/5-LOX inhibitors.