38939-64-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione is used as a therapeutic agent for the treatment of heart failure and cardiovascular conditions. It is utilized for its ability to inhibit the breakdown of cAMP, thereby improving heart function and reducing symptoms associated with heart failure.
Used in Cardiology Research:
In the field of cardiology, 2-(4-PyridinylMethoxy)-1H-Iioindole-1,3(2H)-dione is used as a research compound to explore its potential applications and benefits in treating various cardiovascular conditions. Its mechanism of action, which involves the inhibition of cAMP breakdown, is of particular interest for developing new treatment strategies for heart failure and related disorders.

Upstream product

• 586-95-8 pyridine-4-methanol 
• 524-38-9 N-hydroxyphthalimide 

Downstream Products

• 16115-54-1 O-(pyridin-4-ylmethyl)hydroxylamine dihydrochloride 

Relevant academic research and scientific papers

TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL

It is intended to provide a compound that exhibits a strong antibacterial spectrum against various bacteria including gram-negative bacteria, or a pharmaceutical composition having an antibacterial activity against carbapenem-resistant bacteria. The present invention provides a compound represented by formula (I): wherein -W- is -S(=O)- or -S(=O)2-, -T- is -CR4AR4B- or -CR5AR5B-CR6AR6B-, R4A, R4B, R5A, R5B, R6A and R6B are each independently a hydrogen atom or the like, R1 is substituted or unsubstituted heterocyclyl or the like, R2A and R2B are each independently a hydrogen atom or the like, or R2A and R2B are taken together to form substituted or unsubstituted methylidene or the like, and R3 is a hydrogen atom or the like, R11 is carboxy or the like, R7A and R7b are each independently a hydrogen atom or the like, its ester form or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

PHARMACEUTICAL COMPOSITION CONTAINING TRICYCLIC COMPOUND HAVING SULFINYL OR SULFONYL

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that has antibacterial activity against carbapenem-resistant bacteria. SOLUTION: A pharmaceutical composition contains a compound represented by formula (I), its ester body or their pharmaceutically acceptable salts, or their hydrates (W is S(=O) or S(=O)2; T is CR4AR4B or CR5AR5B-CR6AR6B; R4A, R4B, R5A, R5B, R6A and R6B independently represent halogen, hydroxy, carbonyl, alkyl, cycloalkyl, aryl or the like; R1 is a carbocycle or heterocycle; R2A and R2B independently represent H, amino, hydroxy and the like, or R2A and R2B together form methylidene, hydroxyimino and the like; R3 is H, methoxy or the like). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

SUBSTITUTED GUANIDINE DERIVATIVE

The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

ESTRATRIENE DERIVATIVES

Compounds and methods for modulating mesenchymal cell function, for instance smooth muscle and fibroblast proliferation or cytokine expression, and for treating conditions associated with mesenchymal cell function, for instance airway hyperresponsiveness

Carbamates of rapamycin

A compound of the structure STR1 wherein R1 and R2 are each, independently, hydrogen, or --CONH--O--(CR3 R4)m Z; R3 and R4 are each, independently, hydrogen, alkyl, cycloalkyl, --CF3, or F; Z is hydrogen, alkyl, --OR5, --SR5, --NRSR6, --CN, --CF3, --OAr, --Ar, or R7 ; R5 and R6 are each, independently, hydrogen, alkyl, arylalkyl, alkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl, or Ar; R7 STR2 or --C C--R11 ; R8, R9, R10, and R11 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, or phenyl, wherein the phenyl group may be optionally mono-, di-, or tri-substituted; Ar is an aryl radical that may be optionally mono-, di-, or tri-substituted; and m=1-6; with the proviso that R1 and R2 are both not hydrogen, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.