38940-26-0Relevant academic research and scientific papers
Use of protease from Bacillus licheniformis as promiscuous catalyst for organic synthesis: Applications in C-C and C-N bond formation reactions
Lopez-Iglesias, Maria,Busto, Eduardo,Gotor, Vicente,Gotor-Fernandez, Vicente
experimental part, p. 2345 - 2353 (2011/10/19)
Commercially available protease from Bacillus licheniformis has been used in different non-conventional biotransformations showing remarkable activity values. The promiscuous behaviour of this enzyme used in the cross-linked enzyme aggregates immobilized form (Alcalase-CLEA), has been successfully demonstrated for the first time in C-C bond formation processes such as aldol, Henry and Mannich reactions. On the other hand, the Bayllis-Hillman reaction between 4-nitrobenzaldehyde and methyl vinyl ketone occurred through unspecific catalysis. Interestingly, aza- Michael addition reactions of secondary amines (diethylamine, piperidine and pyrrolidine) to acrylonitrile have been also efficiently catalyzed, observing with diethylamine the most remarkable differences between the enzyme-mediated reaction and the one in the absence of catalyst. Higher reactivities were attained with pyrrolidine demonstrating the versatility of hydrolases in organic synthesis. Copyright
Lipase-catalysed direct Mannich reaction in water: Utilization of biocatalytic promiscuity for C-C bond formation in a "one-pot" synthesis
Li, Kun,He, Ting,Li, Chao,Feng, Xing-Wen,Wang, Na,Yu, Xiao-Qi
supporting information; experimental part, p. 777 - 779 (2010/04/23)
A novel lipase-catalysed direct Mannich reaction has been developed under aqueous conditions in a "one-pot" strategy. Interestingly, these promiscuous reactions can be greatly promoted by water and generally require aromatic aldehydes.
Synthesis of β-amino ketones by iridium(III)-catalyzed direct-Mannich reaction
Sueki, Shunsuke,Igarashi, Takeyuki,Nakajima, Takayuki,Shimizu, Isao
, p. 682 - 683 (2007/10/03)
The direct-Mannich reaction of ketones 1, aldehydes 2, and anilines 3 was studied using catalytic amount of transition-metal complexes. The trivalent iridium complex, [IrCl2(H)(COd)]2, catalyzed the direct-Mannich reaction effectively to give various β-amino kenotes in good yields under mild conditions. Copyright
