38940-28-2Relevant articles and documents
Synthesis of β-aminoketones and construction of highly substituted 4-piperidones by mannich reaction induced by persistent radical cation salts
Jia, Xiao-Dong,Wang, Xiao-E.,Yang, Cai-Xia,Huo, Cong-De,Wang, Wen-Juan,Ren, Yan,Wang, Xi-Cun
supporting information; experimental part, p. 732 - 735 (2010/04/02)
A Mannich reaction of imines and ketones induced by persistent radical cation salts was Investigated, and a series of Mannich bases, β-amlnoketones, were synthesized. A novel cyclization to form the 4-piperidone skeleton was achieved In a tandem process. The reaction can be rationalized as a radical cation process supported by various evidence.