38941-96-7Relevant academic research and scientific papers
Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid
Nelson, Peter H.,Carr, Stephen F.,Devens, Bruce H.,Eugui, Elsie M.,Franco, Fidencio,Gonzalez, Carlos,Hawley, Ronald C.,Loughhead, David G.,Milan, David J.,Papp, Eva,Patterson, John W.,Rouhafza, Sussan,Sjogren, Eric B.,Smith, David B.,Stephenson, Rebecca A.,Talamas, Francisco X.,Waltos, Ann-Marie,Weikert, Robert J.,Wu, John C.
, p. 4181 - 4196 (2007/10/03)
Structure-activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored. Replacement of the lactone ring with other cyclic moieties resulted in loss of potency, especia
FUNTIONALIZATION OF ISOPHORONE INVOLVING POLYCHLORINATION. PART II: Chlorination of Isophorone in the 2- and 6-position involving addition of chlorine to the double bond. Enol allyl rearrangements and base-induced substitution of the 6-chloro atom.
Buyck, L. De,Bostoen, R.,Lecluse, M.,Pooter, H. De,Schamp, N.
, p. 663 - 674 (2007/10/02)
Using trans-2,3-dichloro-3,5,5-trimethylcyclohexanone (2) as an intermediate, isophorone (1) was converted into the 2-chloro derivative 6 (85-93percent), the 2,6-dichloro derivative 5 (65-75percent) and the 2,6,6-trichloro derivative 10 (60-70percent) (is
2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution
Stokker,Deana,deSolms,Schultz,Smith,Cragoe Jr.,Baer,Ludden,Russo,Scriabine,Sweet,Watson
, p. 1414 - 1427 (2007/10/02)
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.
