38943-55-4Relevant academic research and scientific papers
Synthesis and pharmacological study of adamantyl benzene propanamines and propenamines
Pouli,Fytas,Foscolos,Kolocouris,Marakos,Vamvakides
, p. 163 - 169 (2007/10/02)
gamma-(1-Adamantyl)benzenepropanamines and gamma-(1-adamantyl)benzene-beta-propenamines were synthesized and their pharmacological action was studied on mice. Behavioral effects obtained with these compounds and specially the study of convulsions, induced by these derivatives, could show a rise of the gamma-(1-adamantyl)benzenepropanamine's antinicotinic component, which is characteristic of all the adamantanamines. On the contrary gamma-(1-adamantyl)benzene-beta-propenamine's molecular torsion, induced by the double bond, coudl confer to these derivatives agonistic properties on the central nicotinic receptor sites.
