38946-73-5

Upstream product

• 81691-57-8 L-eritadenine methyl ester 
• 28875-69-6 2,3-O-cyclohexylidene-D-erythronolactone 
• 66224-66-6 adenine 
• 193410-07-0 5-(6-amino-purin-9-ylmethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 
• 55174-83-9 5-(Adenin-9-yl)-5-deoxy-1,2-O-isopropylidene-L-arabinofuranose 
• 184227-81-4 4-(adenin-9-yl)-2,3-isopropylidenedioxybutanal 
• 151359-36-3 9-[(2S,3R,4R)-(5,4-dihydroxy-2,3-isopropylidenedioxy)pentyl]adenine 

Downstream Products

• 81739-10-8 9-(2S,3R)-erythro-(4-O-p-toluenesulfonyl-2,3-O-isopropylidene-2,3,4-trihydroxybutyl)adenine 

Relevant academic research and scientific papers

A Novel Approach for the Synthesis of Purine Acyclonucleosides Using 9-D-Ribitylpurines as a Chiral Pool

Facile syntheses of L-eritadenine (8a), (2S,3R)-9-(2,3,4-trihydroxybutyl)purines (4a and 4b), and (2S,3S)-9-(2,3,4-trihydroxybutyl)adenine (6a) were achieved by using 9-D-(23-O-isopropylideneribityl)purines (1a and 1b) as a chiral pool.

Novel synthesis of purine acyclonucleosides possessing a chiral 9-hydroxyalkyl group by sugar modification of 9-D-ribitylpurines

A novel approach to the synthesis of purine acyclonucleosides having chiral carbons in the N9-hydroxyalkyl chain was achieved by using 9-(2,3-O-isopropylidene-D-ribityl)purines 1, which are readily prepared from commercially available purine nucleosides. 9-[(2S,3.R)-2,3,4-Trihydroxybutyl]purines 4a and 4b, 9-[(2S,3S)-2,3,4-trihydroxybutyl]purines 6a and 6b, L-eritadenine 8, and its analogue 11 are conveniently synthesized via key intermediates, (2S,3S)-2,3-isopropylidenedioxy-4-(purin-9-yl)butanals 2 prepared by NaIO4 oxidation of diols 1.