38954-75-5Relevant academic research and scientific papers
Glucosyl-gemini nonionic surfactant and synthesis method thereof
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Paragraph 0068; 0069; 0080, (2018/03/01)
The invention discloses a glucosyl-gemini nonionic surfactant and a synthesis method thereof. The glucosyl-gemini nonionic surfactant is obtained by performing a reaction on bis(C8-C18 long-chain alkyl glyceryl ether) diamine and glucolactone; the glucosyl-gemini nonionic surfactant combines the advantages of mild and no-irritating texture, high possibility of biodegradation and environmental friendliness of a sugar-based surfactant and also has excellent performances of a gemini surfactant for further improving the surface activity, lowering the critical micelle concentration and the like, and therefore, the glucosyl-gemini nonionic surfactant is a multi-functional surfactant; the glucosyl-gemini nonionic surfactant can be widely applied in the industries of chemicals for daily use, petroleum, pesticides, spinning, paper making, mining and the like, and therefore, the glucosyl-gemini nonionic surfactant has a broad application prospect.
Synthesis, Surface and Antimicrobial Activities of Novel Cationic Gemini Surfactants
Ding, Zhaoyun,Fang, Shimin
, p. 1051 - 1057 (2015/11/18)
A series of novel cationic gemini surfactants [C n H2n+1-O-CH2-CH(OH)-CH2-N+(CH3)2-(CH2)2]2·2Br- [3a (n = 12), 3b (n = 14) and 3c (n = 16)] having a 2-hydroxy-1,3-oxypropylene group [-CH2-CH(OH)-CH2-O-] in the hydrophobic chain have been synthesized and characterized. Their water solubility, surface activity, foaming properties, and antibacterial activity have been examined. The critical micelle concentration (CMC) values of the novel cationic gemini surfactants are one to two orders of magnitude smaller than those of the corresponding monomeric surfactants. Furthermore, the novel cationic gemini surfactants have better water solubility and surface activity than the comparable [C n H2n+1-N+(CH3)2-(CH2)2]2·2Br- (n-4-n) geminis. The novel cationic gemini surfactants 3a and 3b also exhibit good foaming properties and show good antibacterial and antifungal activities.
Synthesis, characterization and evaluation of the surface active properties of novel cationic imidazolium gemini surfactants
Patial, Pankaj,Shaheen, Arifa,Ahmad, Ishtiaque
, p. 253 - 260 (2014/03/21)
New imidazolium gemini surfactants were synthesized by reaction of epichlorohydrin with long chain fatty alcohols furnishing products 2-(alkoxymethyl)oxirane followed by their subsequent treatment with imidazole resulting in the formation of 1-(1H-imidazol-1-yl-3 alkoxy)propane-2-ol which on subsequent treatment with 1,2-dibromoethane and 1,3-dibromopropane resulted in the formation of title gemini surfactants:1,2-bis(1(3-alkoxy-2-hydroxypropyl)- 1H-imidazol-3-ium)ethane bromide (7), 1,3-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (8), 1,2-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)ethane bromide (9), 1,3-bis(1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (10), 1,2-bis (1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)ethane bromide (11) and 1,3-bis (1(3-alkoxy-2-hydroxypropyl)-1H- imidazol-3-ium)propane bromide (12). Their identification was based on IR, 1H-, 13C-NMR, DEPT, COSY and mass spectral studies. Their surface active properties were also evaluated on the basis of surface tension and conductivity measurements.
Chemo-enzymatic synthesis and antimicrobial evaluation of alkyloxy propanol amine-based cationic ether lipids
Reddy,Rao,Karuna,Kumar,Murthy,Prasad
, p. 437 - 448 (2013/07/27)
The present study involved the synthesis and antimicrobial evaluation of alkyloxy propanol amine-based cationic lipids N,N-dimethyl-1-octadecylamino-3- alkyloxy-2-propanol (series A, 7a-e) and N-methyl-N,N-di-(2-hydroxy-3-alkyloxy-2 propyl) octadecylamine (series B, 9a-e) and their acetylated derivatives (8a-e and 10a-e). A simple three-step chemo-enzymatic approach was employed for the synthesis of 7a-e and 9a-e in 71-80 and 67-88 % yields, respectively. The first step involved the synthesis of a series of glycidyl ethers from a series of alcohols (C4, C8, C10, C12, C 14) which were opened in the second step with octadecylamine to obtain 1-octadecylamino-3-alkyloxy-2 propanol (5a-e) and N,N-di-(2-hydroxy-3- alkyloxypropyl) octadecylamine (6a-e). In the third step, alkyloxy propanolamines (5a-e, 6a-e) were quaternized using methyl iodide to yield quaternized ammonium salts. The quaternized ammonium salts were enzymatically acetylated using Candida antarctica lipase-B based immobilized enzyme Novozym 435 to obtain their acetylated derivatives. The quaternized salts as well as their acetylated derivatives were evaluated for antibacterial and antifungal properties. The title compounds were found to possess moderate to good antibacterial activities against all the studied bacterial strains namely, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella aerogenes compared to streptomycin and cetyl trimethyl ammonium bromide (CTAB). The title compounds exhibited relatively good antifungal activities against Candida albicans and no significant activities against other fungal strains namely, Saccharomyces cerevisiae, Rhizopus oryzae and Aspergillus niger when compared to amphotericin B and CTAB.
Physicochemical properties of novel phosphobetaine zwitterionic surfactants and mixed systems with an anionic surfactant
Nong, Lanping,Xiao, Chengliang,Zhong, Zhensheng
experimental part, p. 433 - 438 (2012/07/14)
A series of novel zwitterionic phosphobetaine (PPBT) surfactants were synthesized using long chain fatty alcohol, epichlorohydrin, dimethylamine and sodium dihydrogen phosphate as raw materials. The physicochemical properties of the phosphobetaine surfactants such as isoelectric point, foaming, surface tension, critical micelle concentration (CMC) and Krafft point were measured. Low CMC and surface tension values indicated the surface activities of the phosphobetaine surfactants were quite excellent. The CMC and surface tension values of PPBT/SDS mixed systems were determined. It was found both of CMC and surface tension values decreased compared with single surfactant system because of the association between dodecyl sulfate anions and cationic groups in phosphobetaine by electrostatic attraction. AOCS 2011.
Synthesis and thermotropic properties of novel double-chained quaternary ammonium chlorides with symmetric and asymmetric hydrocarbon chain length
Ding, Zhaoyun,Hao, Aiyou
scheme or table, p. 127 - 131 (2009/09/30)
A series of novel double-chained quaternary ammonium chlorides with symmetrical and asymmetrical hydrocarbon chain length R1-O-CH2-CH(OH)-CH2-N+(CH3)2-R2·Cl- (R1, R2: C12H25, C14H29, C16H33) have been synthesized by the reaction of 1-O-alkyl glycidyl ether with N,N-dimethylalkylamine and N,N-dimethylalkylamine hydrochloride. Their chemical structures have been characterized through FT-IR, 1H NMR, MS and elementary analysis. Their thermotropic properties have been examined by differential scanning calorimetry (DSC), polarizing light microscopy (PLM) and X-ray diffraction (XRD). It has been found that the compounds with longer hydrocarbon chain length and being higher asymmetry in hydrocarbon chain length exhibit lower melting point (Tm), isotropization temperature (Ti) and narrower mesophase temperature range. However, the hydrocarbon chain length and the symmetry in the hydrocarbon chain length have little influence on the type of liquid crystals. All compounds form cholesteric liquid crystal.
Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
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, (2008/06/13)
The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
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, (2008/06/13)
The present invention provides therapeutic compositions containing lysophosphotidic acids, methods for making the compositions, and methods of using the compositions in the preservation and treatment of organs.
A Halide-Free Method for Olefin Epoxidation with 30% Hydrogen Peroxide
Sato, Kazuhiko,Aoki, Masao,Ogawa, Masami,Hashimoto, Tadashi,Panyella, David,Noyori, Ryoji
, p. 905 - 915 (2007/10/03)
A catalytic system consisting of sodium tungstate dihydrate, (aminomethyl) phosphonic acid, and methyltrioctylammonium Hydrogensulfate, effects the epoxidation of olefins using 30% hydrogen peroxide with a substrate-to-catalyst molar ratio of 50 - 500. The reaction proceeds in high yield without solvents, or, alternatively, with added toluene under entirely halide-free conditions. Lipophilic ammonium hydrogensulfate, which replaces the conventional chloride, and an (α-aminoalkyl)phosphonic acid are crucial for the high reactivity. This method is operationally simple, environmentally benign, and much more economical than the oxidation with m-chloroperbenzoic acid, allowing for a large-scale preparation of epoxides. Various substrates including terminal olefins, 1,1- and 1,2-disubstituted olefins, cyclic olefins, and tri- and tetrasubstituted olefins as well as allylic alcohols, esters, α,β-unsaturated ketones, and ethers can be epoxidized in high yield. The scope and limitations of this new reaction system are discussed.
Single step etherification of fatty alcohols by an epihalohydrin
Najem,Borredon
, p. 3021 - 3030 (2007/10/02)
A new, single step synthesis of glycidyl ethers from an epihalohydrin (X = Cl, Br) and seven fatty alcohols is proposed in a poorly hydrated solid/liquid heterogeneous basic medium. The selectivity and the yields of the reaction are high. The structural analysis and the physicochemical characteristics of the synthesized products are reported.
