38956-37-5Relevant academic research and scientific papers
External Oxidant-Free Regioselective Cross Dehydrogenative Coupling of 2-Arylimidazoheterocycles and Azoles with H2 Evolution via Photoredox Catalysis
Chen, Hong,Yi, Hong,Tang, Zilu,Bian, Changliang,Zhang, Heng,Lei, Aiwen
supporting information, p. 3220 - 3227 (2018/08/03)
In this work, we achieved a site-selective amination of 2-arylimidazoheterocycles on the C3 position using photo-induced external oxidant-free strategy. The C?N bond formation with H2 evolution was realized via the oxidative C?H/N?H coupling. This protocol may have significant implications in the late-modification of complicated drug molecules. In addition, we also used CV and DFT calculations to study the mechanism, which showed that the arene radical cation played an important role in accelerating the C?H amination process. (Figure presented.).
Metal-free C-N bond formations: One-pot synthesis of pyrido[2′,1′:2,3]imidazo[4,5-: C] cinnolines, benzo[4′,5']thiazolo- and thiazolo[2′,3′:2,3]imidazo[4,5- c] cinnolines
Kandimalla, Satheeshkumar Reddy,Sabitha, Gowravaram
, p. 67086 - 67095 (2016/07/30)
An efficient one-pot synthesis of novel pyrido[2′,1′:2,3]imidazo[4,5-c]cinnoline derivatives has been achieved with moderate to good yields, with two C-N bond formations through C-H functionalization of 2-arylimidazo[1,2-a]pyridines. The reaction proceeds via C-3 regioselective hydrazination with diisopropyl azodicarboxylate followed by oxidative N-arylation mediated by phenyliodine(iii) diacetate (PIDA) in trifluoroacetic acid by means of C-H functionalization to produce pyrido[2′,1′:2,3]imidazo[4,5-c]cinnolines. Other imidazoheterocycles such as 2-arylbenzo[d]imidazo[2,1-b]thiazoles, and 6-arylimidazo[2,1-b]thiazoles underwent similar transformations giving the corresponding cinnolines under transition metal-free and mild conditions.
Synthesis and SAR study of imidazo[2,1-b]benzothiazole acids and some related compounds with anti-inflammatory and analgesic activities
Palagiano,Arenare,De Caprariis,Grandolini,Ambrogi,Perioli,Filippelli,Falcone,Rossi
, p. 483 - 491 (2007/10/03)
Some (un)substituted imidazo[2,1-b]benzothiazole carboxylic or acetic acids and some related compounds, i.e. imidazo[2,1-b]naphtho[2,1-d]thiazole, 4H-imidazo[2,1-c][1,4]benzothiazine, 4,5-dihydroimidazo[2,1-d][1,5]benzothiazepine carboxylic and acetic aci
