389602-90-8

Basic information

• Product Name: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE
• Synonyms: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE
• CAS NO: 389602-90-8
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol File: 389602-90-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 396.5°Cat760mmHg
• Flash Point: 213.4°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 1.71E-06mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE(389602-90-8)
• EPA Substance Registry System: 4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE(389602-90-8)

Safety Data

• Hazardous Substances Data: 389602-90-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H19NO2/c15-13-3-1-11(2-4-13)12-5-7-14(8-6-12)16-9-10-17-14/h1-4,12H,5-10,15H2

Upstream product

• 56309-94-5 8-(4-oxocyclohexyl)-1,4-dioxaspiro[4.5]decane 
• 92159-87-0 benzyl (4-bromophenyl)carbamate 
• 680596-79-6 4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane 
• 959939-45-8 benzyl ((4-(1,4-dioxaspiro)[4.5] dec-7-en-8-yl)phenyl)carbamate 

Downstream Products

• 959939-46-9 N,N-dibenzyl-4-(1,4-dioxaspiro[4.5]dec-8-yl)aniline 
• 959939-51-6 methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate 
• 959939-47-0 4-[4-(dibenzylamino)phenyl]cyclohexan-1-one 
• 959939-48-1 trans-4-[4-(dibenzylamino)phenyl]cyclohexan-1-ol 
• 959939-52-7 methyl trans-3-[4-[4-[(methoxycarbonylformyl)amino]phenyl]cyclohexyl]oxypropanoate 
• 959939-53-8 methyl trans-3-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]-cyclohexyl]oxypropanoate 
• 959939-50-5 methyl trans-3-[4-[4-(dibenzylamino)phenyl]cyclohexyl]oxypropanoate 
• 959939-54-9 methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate 
• 959939-49-2 tert-butyl trans-3-[4-[4-(dibenzylamino)phenyl]cyclohexyl]oxypropanoate 

Relevant articles and documents

Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis

The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

Selective Synthesis of Primary Anilines from NH3 and Cyclohexanones by Utilizing Preferential Adsorption of Styrene on the Pd Nanoparticle Surface

Dehydrogenative aromatization is one of the attractive alternative methods for directly synthesizing primary anilines from NH3 and cyclohexanones. However, the selective synthesis of primary anilines is quite difficult because the desired primary aniline products and the cyclohexanone substrates readily undergo condensation affording the corresponding imines (i.e., N-cyclohexylidene-anilines), followed by hydrogenation to produce N-cyclohexylanilines as the major products. In this study, primary anilines were selectively synthesized in the presence of supported Pd nanoparticle catalysts (e.g., Pd/HAP, HAP=hydroxyapatite, Ca10(PO4)6(OH)2) by utilizing competitive adsorption unique to heterogeneous catalysis; in other words, when styrene was used as a hydrogen acceptor, which preferentially adsorbs on the Pd nanoparticle surface in the presence of N-cyclohexylidene-anilines, various structurally diverse primary anilines were selectively synthesized from readily accessible NH3 and cyclohexanones. The Pd/HAP catalyst was reused several times though its catalytic performance gradually declined.

BENZIMIDAZOLES AND THEIR USE FOR THE TREATEMNT OF DIABETES

Compounds of formula (I), or salts thereof, which inhibit acetyl CoA(acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, (A chemical formula should be inserted here - please see paper copy enclosed herewith) (I) wherein: Rsup