389631-20-3Relevant academic research and scientific papers
New synthesis and ring opening of cis-3-alkylaziridine-2-carboxylates
Lee, Kwang-Deuk,Suh, Jang-Min,Park, Jae-Hoon,Ha, Hyun-Joon,Choi, Hwan Gun,Park, Chan Sun,Chang, Jae Won,Lee, Won Koo,Dong, Yongkwan,Yun, Hoseop
, p. 8267 - 8276 (2007/10/03)
Syntheses of cis-3-alkylaziridine-2-carboxylates including cis-3-benzyl- and cis-3-phenylaziridine-2-carboxylates were achieved from the reaction of α-aminonitrile and alkyldiazoacetate in the presence of a Lewis acid. Asymmetric version of this reaction with the chiral α-methylbenzylamine was also successful for the preparation of chiral aziridines that were used for the synthesis of various amino acids including homophenylalanine, β-amino-α-hydroxy acid, α,β-diamino acid, and α-amino-β-hydroxy acid via regioselective aziridine ring openings.
