612836-84-7

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 246522-97-4 (2R/S)-3-phenyl-2-<(R)-1-phenylethylamino>propanenitrile 
• 200286-34-6 2-Oxo-4-phenyl-3-phenylselanyl-butyric acid ethyl ester 
• 38235-77-7 (R)-N-benzyl-1-phenylethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 54966-42-6 ethyl 3-benzylacrylate 
• 884318-64-3 ethyl 2-((R)-1-phenylethylimino)-4-phenyl-3-(phenylselanyl)butanoate 
• 884318-80-3 (R)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-4-phenylbutanoate 
• 884318-82-5 (R)-ethyl 3-(N-((R)-1-phenylethyl)amino)-4-phenylpentanoate 
• 884318-91-6 (2S,3R)-ethyl 4-phenyl-3-(N-((R)-1-phenylethyl)amino)-2-(phenylselanyl)butanoate 
• 884318-71-2 (2S,3S)-ethyl 2-((R)-1-phenylethylamino)-4-phenyl-3-(phenylselanyl)butanoate 

Downstream Products

• 389631-27-0 ethyl (2R,3R)-3-acetyloxy-2-N-tert-butoxycarbonylamino-4-phenylbutanoate 
• 389631-25-8 ethyl (2R,3R)-3-acetyloxy-4-phenyl-2-[(R)-1-phenylethylamino]butanoate 
• 389631-20-3 2-benzyl-1-[(R)-1-phenylethylamino]-3-vinylaziridine 

Relevant academic research and scientific papers

Diastereoselective synthesis of aziridine esters via amino selanyl esters

A synthesis of aziridine esters based on the cyclisation of amino selanyl esters induced by the selanyl group activation was developed with either the Meerwein salt or NBS. Two asymmetric approaches are proposed: the diastereoselective reductions of α-sel

New synthesis and ring opening of cis-3-alkylaziridine-2-carboxylates

Syntheses of cis-3-alkylaziridine-2-carboxylates including cis-3-benzyl- and cis-3-phenylaziridine-2-carboxylates were achieved from the reaction of α-aminonitrile and alkyldiazoacetate in the presence of a Lewis acid. Asymmetric version of this reaction with the chiral α-methylbenzylamine was also successful for the preparation of chiral aziridines that were used for the synthesis of various amino acids including homophenylalanine, β-amino-α-hydroxy acid, α,β-diamino acid, and α-amino-β-hydroxy acid via regioselective aziridine ring openings.