38969-65-2

Usage

Uses

Used in Pharmaceutical Industry:
()-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline is used as a potential pharmaceutical candidate for various applications due to its unique molecular structure and the presence of functional groups that may interact with biological targets. Its isoquinoline core and substituents could potentially modulate specific signaling pathways or exhibit inhibitory effects on certain biological processes, making it a promising compound for drug development.
However, it is important to note that the specific applications and reasons for using ()-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline in the pharmaceutical industry are not provided in the materials. Further research and testing would be necessary to determine its exact properties, potential therapeutic effects, and safety profile before it can be utilized in any specific applications.

Upstream product

• 118646-97-2 1-(4-methoxy-benzyl)-2-methyl-1,2,3,4,6,7,8,8a-octahydro-isoquinoline 
• 118646-96-1 (2-cyclohex-1-enyl-ethyl)-(4-methoxy-styryl)-methyl-amine 
• 98237-33-3 1-(4-Methoxybenzyl)-2-methyl-5,6,7,8-tetrahydroisochinoliniumiodide 
• 50-00-0 formaldehyd 
• 51072-36-7 (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 14467-91-5 2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 824-94-2 p-methoxybenzyl chloride 
• 101871-19-6 (2-cyclohex-1-enyl-ethyl)-methyl-amine 
• 102448-99-7 N-(2-(cyclohex-1-en-1-yl)ethyl)-1,1-diphenylmethanimine 
• 7339-87-9 4-hydroxyphenylacetaldehyde 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 110252-37-4 N-methyl-5,6,7,8-tetrahydroisoquinolinium iodide 

Downstream Products

• 23667-36-9 6-methyl-2,3,3a,4,5,6,6a,7,11b,11c-decahydro-1H-dibenzo[de,g]quinolin-10-ol 
• 77-07-6 racemorphan 
• 23667-36-9 (+/-)-6-methyl-(3ar,6at,11bt,11ct)-2,3,3a,4,5,6,6a,7,11b,11c-decahydro-1H-dibenzo[de,g]quinolin-10-ol 
• 125-70-2 rac-3-methoxy-17-methyl-morphinane 
• 89614-56-2 (S)-(+)-N-methyl-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 67596-84-3 (+)-2-methyl-1-(4-methoxy)benzyl-1,2,3,4,5,6,7,8-hexahydroisoquinoline 
• 125-70-2 dextromethorphan 
• 852334-50-0 {2-[2-(4-methoxy-phenethyl)-cyclohexyl]-ethyl}-methyl-amine 
• 95367-72-9 {2-[2-(4-methoxy-phenethyl)-cyclohexyl]-ethyl}-dimethyl-amine 
• 102021-29-4 {2-[2-(4-methoxy-styryl)-cyclohex-1-enyl]-ethyl}-dimethyl-amine 
• 98985-27-4 rac-3-benzyloxy-17-methyl-morphinane 
• 77-07-6 Levorphanol 
• 67553-46-2 (+/-)-4-(2-methyl-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol 
• 51072-36-7 (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline 

Relevant academic research and scientific papers

Preparation method of 1-(4-methoxy-benzyl)-2-methyl-octahydro isoquinoline

The invention discloses a preparation method of 1-(4-methoxy-benzyl)-2-methyl-octahydro isoquinoline. The preparation method comprises the following steps: dissolving 1, 2, 3, 4, 5, 6, 7, 8-octahydro-1-(methoxyphenyl) methyl isoquinoline in a solvent, adding a formaldehyde solution, stirring, adding a catalyst, introducing hydrogen, carrying out a catalytic hydrogenation reaction, filtering the catalyst out after the reaction is finished, desolventizing, and carrying out distillation separation to obtain 1-(4-methoxyl-benzyl)-2-methyl-1, 2, 3, 4, 5, 6, 7, 8-octahydro isoquinoline. The method provided by the invention has the characteristics of mild and safe reaction conditions, environmental protection, side reaction reduction, high yield, good purity, simple operation and the like, so that the preparation industry is green, environment-friendly, safe and efficient, and the production cost is reduced.

Preparation of useful intermediates of dextrorphan - Note I

Dextrorphan is the main metabolite of Dextromethorphan, a drug with high anti-tussive activity. In this preliminary work we report on the synthesis of two essential intermediates for its preparation: 2-(1-cyclohexenyl)ethyl amine and (R;S)-1-(4-methoxy-benzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinol ine.

Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline

N-Alkyl allylic tertiary amines are dealkylated as illustrated by treatment of (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline in cold methylene chloride with m-chloroperbenzoic acid followed by the addition of aqueous ferrous chloride to provide a good yield of (+)-1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline with substantial if not complete retention of optical activity. The product is an intermediate in a synthesis of the analgesic known as butorphanol.