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125-70-2 Usage

Uses

The enatiomer of Dextromethorphan (D299455), an antitussive medicine, a narcotic.

Check Digit Verification of cas no

The CAS Registry Mumber 125-70-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 5 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 125-70:
(5*1)+(4*2)+(3*5)+(2*7)+(1*0)=42
42 % 10 = 2
So 125-70-2 is a valid CAS Registry Number.

InChI:InChI=1/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m0/s1

125-70-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	Levomethorphan

1.2 Other means of identification

Product number	-
Other names	6-methoxy-17-methyl-morphinan

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:125-70-2 SDS

125-70-2Upstream product

125-70-2Downstream Products

125-70-2Related news

ReviewEnantioselective interactions of dextromethorphan and levomethorphan (cas 125-70-2) with the α3β4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data09/10/2019

The enantioselectivity of the interaction of dextromethorphan (DM) and levomethorphan (LM) with an immobilized α3β4 subtype of the nicotinic acetylcholine receptor (nAChR) liquid chromatographic stationary phase has been compared to DM- and LM-induced non-competitive blockade of nicotine-stimu...detailed

NotesDetermination of Dextro- and levomethorphan (cas 125-70-2) Mixtures Using Chiral Lanthanide NMR Shift Reagents09/09/2019

Europium and praseodymium chiral NMR shift reagents were used to differentiate between dextro- and levomethorphan. The enantiomeric shift differences (ΔΔδ) demonstrated by the singlet associated with the methoxy protons were large enough to identify the levo- and dextro-isomers and to allow f...detailed

Short communicationDetermination of dextromethorphan and levomethorphan (cas 125-70-2) in seized heroin samples by enantioselective HPLC and electronic CD09/08/2019

A new enantioselective HPLC method was developed for the resolution and determination of the enantiomers of methorphan, dextromethorphan (DXM) and levomethorphan (LVM), on a Chiralcel® OJ column (250 mm × 4.6 mm I.D.). The resolution of DXM and LVM was obtained using a mobile phase consisting o...detailed

125-70-2Relevant articles and documents

-

Schnider,Gruessner

, p. 2211,2217 (1951)

Bien,S.,Ginsburg,D.

, p. 2065 - 2068 (1963)

Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine dependence

Neumeyer, John L.,Bidlack, Jean M.,Zong, Rushi,Bakthavachalam, Venkatesalu,Gao, Peng,Cohen, Dana J.,Negus, S. Stevens,Mello, Nancy K.

, p. 114 - 122 (2000)

This report concerns the synthesis and preliminary pharmacological evaluation of a novel series of K agonists related to the morphinan (-)- cyclorphan (3a) and the benzomorphan (-)cyclazocine (2) as potential agents for the pharmacotherapy of cocaine abuse. Recent evidence suggests that agonists acting at κ opioid receptors may modulate the activity of dopaminergic neurons and alter the neurochemical and behavioral effects of cocaine. We describe the synthesis and chemical characterization of a series of morphinans 3a-c, structural analogues of cyclorphan [(-)-3-hydroxy-N- cyclopropylmethylmorphinan S(+)-mandelate, 3a], the 10-ketomorphinans 4a,b, and the 8-ketobenzomorphan 1b. Binding experiments demonstrated that the cyclobutyl analogue 3b [(-)-3-hydroxy-N-cyclobutylmethylmorphinan S(+)- mandelate, 3b, MCL-101] of cyclorphan (3a) had a high affinity for μ, δ, and κ opioid receptors in guinea pig brain membranes. Both 3a,b were approximately 2-fold more selective for the κ receptor than for the μ receptor. However 3b (the cyclobutyl analogue) was 18-fold more selective for the κ receptor in comparison to the δ receptor, while cyclorphan (3a) had only 4-fold greater affinity for the κ receptor in comparison to the δ receptor. These findings were confirmed in the antinociceptive tests (tail- flick and acetic acid writhing) in mice, which demonstrated that cyclorphan (3a) produced antinociception that was mediated by the δ receptor while 3b did not produce agonist or antagonist effects at the δ receptor. Both 3a,b had comparable κ agonist properties 3a,b had opposing effects at the μ receptor: 3b was a μ agonist whereas 3a was a μ antagonist.

METHODS FOR PREPARING LEVORPHANOL AND RELATED COMPOUNDS, AND COMPOSITIONS THEREOF

-

Paragraph 0177-0182, (2020/04/29)

A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.

CAS

125-70-2