389824-22-0Relevant academic research and scientific papers
Structure-guided design of N-phenyl tertiary amines as transrepression- selective liver X receptor modulators with anti-inflammatory activity
Chao, Esther Y.,Caravella, Justin A.,Watson, Mike A.,Campobasso, Nino,Ghisletti, Serena,Billin, Andrew N.,Galardi, Cristin,Wang, Ping,Laffitte, Bryan A.,Iannone, Marie A.,Goodwin, Bryan J.,Nichols, Jason A.,Parks, Derek J.,Stewart, Eugene,Wiethe, Robert W.,Williams, Shawn P.,Smallwood, Angela,Pearce, Kenneth H.,Glass, Christopher K.,Willson, Timothy M.,Zuercher, William J.,Collins, Jon L.
, p. 5758 - 5765 (2008)
A cocrystal structure of T1317 (3) bound to hLXRβ was utilized in the design of a series of substituted N-phenyl tertiary amines. Profiling in binding and functional assays led to the identification of LXR modulator GSK9772 (20) as a high-affinity LXRβ li
