389837-61-0

Basic information

• Product Name: 5-(2-methoxyphenyl)-5-oxo-pentanal
• Synonyms: 5-(2-methoxyphenyl)-5-oxo-pentanal
• CAS NO: 389837-61-0
• Molecular Weight: 206.241
• Mol File: 389837-61-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxyphenyl)-5-oxo-pentanal(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxyphenyl)-5-oxo-pentanal(389837-61-0)
• EPA Substance Registry System: 5-(2-methoxyphenyl)-5-oxo-pentanal(389837-61-0)

Safety Data

• Hazardous Substances Data: 389837-61-0(Hazardous Substances Data)

Upstream product

• 39877-86-6 1-(1-cyclopentenyl)-2-methoxy-benzene 
• 79416-01-6 1-(o-methoxyphenyl)cyclopentanol 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 120-92-3 cyclopentanone 
• 43228-98-4 5-hydroxy-1-(2-methoxyphenyl)pentan-1-one 
• 578-57-4 2-bromoanisole 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 

Downstream Products

• 1396204-24-2 ethyl 2-((2R,6S)-6-(2-methoxyphenyl)tetrahydro-2H-pyran-2-yl)acetate 
• 1396204-36-6 isopropyl 2-((2R,6S)-6-(2-methoxyphenyl)tetrahydro-2H-pyran-2-yl)acetate 
• 1396202-81-5 ethyl 7-(2-methoxyphenyl)-7-oxohept-2-enoate 

Relevant articles and documents

Enantioselective synthesis of 2,6-cis-disubstituted tetrahydropyrans via a tandem catalytic asymmetric hydrogenation/oxa-Michael cyclization: An efficient approach to (-)-centrolobine

A highly efficient one-pot process via a tandem reaction of catalytic asymmetric hydrogenation and oxa-Michael cyclization for the synthesis of 2,6-cis-disubstituted tetrahydropyrans has been developed (ee up to 99.9%, cis/trans-selectivity up to 99:1). T

Stereoselective synthesis of δ-lactones from 5-oxoalkanals via one-pot sequential acetalization, tishchenko reaction, and lactonization by cooperative catalysis of samarium ion and mercaptan

By the synergistic catalysis of samarium ion and mercaptan, a series of 5-oxoalkanals was converted to (substituted) δ-lactones in efficient and stereoselective manners. This one-pot procedure comprises a sequence of acetalization, Tishchenko reaction and lactonization. The deliberative use of mercaptan, by comparison with alcohol, is advantageous to facilitate the catalytic cycle. The reaction mechanism and stereochemistry are proposed and supported by some experimental evidence. Such samarium ion/mercaptan cocatalyzed reactions show the feature of remote control, which is applicable to the asymmetric synthesis of optically active δ-lactones. This study also demonstrates the synthesis of two insect pheromones, (2S,5R)-2-methylhexanolide and (R)-hexadecanolide, as examples of a new protocol for asymmetric reduction of long-chain aliphatic ketones.