38993-84-9

Basic information

• Product Name: (1-METHYL-1H-IMIDAZOL-5-YL)METHANOL
• Synonyms: RARECHEM AL BD 0940;(3-METHYL-3H-IMIDAZOL-4-YL)-METHANOL;5-HYDROXYMETHYL-1-METHYL-1H-IMIDAZOLE;(1-METHYL-1H-IMIDAZOL-5-YL)METHANOL;1-METHYL-5-(HYDROXYMETHYL)IMIDAZOLE;5-(HydroxyMethyl)-1-MethyliMidazole;(3-methylimidazol-4-yl)methanol;1H-Imidazole-5-methanol,1-methyl-
• CAS NO: 38993-84-9
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• Product Categories: blocks;Imidazoles;Imidazol&Benzimidazole
• Mol File: 38993-84-9.mol

Chemical Properties

• Melting Point: 113 °C
• Boiling Point: 324.872 °C at 760 mmHg
• Flash Point: 150.278 °C
• Appearance: /
• Density: 1.167 g/cm³
• Vapor Pressure: 9.76E-05mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 14.35±0.10(Predicted)
• CAS DataBase Reference: (1-METHYL-1H-IMIDAZOL-5-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1-METHYL-1H-IMIDAZOL-5-YL)METHANOL(38993-84-9)
• EPA Substance Registry System: (1-METHYL-1H-IMIDAZOL-5-YL)METHANOL(38993-84-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37/39-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 38993-84-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
(1-Methyl-1H-imidazol-5-yl)methanol is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique imidazole ring structure may offer novel therapeutic properties, although further research is required to explore its pharmacological activity and safety profile.
Used in Chemical Research:
As a novel chemical entity, (1-Methyl-1H-imidazol-5-yl)methanol can be utilized in chemical research to study its reactivity and potential applications in various chemical reactions. Its imidazole alkaloid structure may provide insights into the synthesis of new compounds and the development of innovative chemical processes.
Used in Biochemical Studies:
(1-Methyl-1H-imidazol-5-yl)methanol, due to its imidazole ring, may have potential interactions with biological systems. It can be used in biochemical studies to investigate its binding properties with enzymes, receptors, or other biomolecules, potentially leading to the discovery of new biological activities or mechanisms of action.

InChI:InChI=1/C5H8N2O/c1-7-4-6-2-5(7)3-8/h2,4,8H,3H2,1H3

Upstream product

• 822-55-9 (1H-imidazol-4-yl)methanol 
• 41806-40-0 1-methyl-1H-imidazole-5-carboxylic acid 
• 96-26-4 dihydroxyacetone 
• 5041-09-8 isobutylamine hydrochloride 
• 22680-44-0 (2-chlorophenyl)methanamine monohydrochloride 
• 42365-42-4 3-chloro-benzylamine; hydrochloride 
• 42365-50-4 3-methyl-benzylamine; hydrochloride 
• 26177-45-7 4-methylbenzylamine hydrochloride 
• 18600-40-3 (2-methoxyethyl)amine hydrochloride 
• 50877-01-5 cyclohexanmethylamine hydrochloride 

Downstream Products

• 89180-90-5 5-(chloromethyl)-1-methyl-1H-imidazole 
• 158629-15-3 Benzoic acid 2-benzoyl-3-methyl-3H-imidazol-4-ylmethyl ester 
• 158629-17-5 4-Methyl-benzoic acid 3-methyl-2-(4-methyl-benzoyl)-3H-imidazol-4-ylmethyl ester 
• 158629-16-4 4-Chloro-benzoic acid 2-(4-chloro-benzoyl)-3-methyl-3H-imidazol-4-ylmethyl ester 
• 158629-18-6 4-Methoxy-benzoic acid 2-(4-methoxy-benzoyl)-3-methyl-3H-imidazol-4-ylmethyl ester 
• 158629-19-7 4-Nitro-benzoic acid 3-methyl-2-(4-nitro-benzoyl)-3H-imidazol-4-ylmethyl ester 
• 39021-62-0 1-methylimidazole-5-carbaldehyde 
• 163009-15-2 5-benzoylthiomethyl-1-methyl-imidazole 
• 384821-12-9 5-[(4'-methoxyphenyl)methoxymethyl]-1-methyl-1H-imidazole 
• 384821-11-8 5-methoxymethyl-1-methyl-1H-imidazole 
• 85012-71-1 5-hydroxymethyl-1-methyl-4-nitro-1H-imidazole 

Relevant articles and documents

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

An Effective Chirospecific Synthesis of (+)-Pilocarpine from L-Aspartic Acid

A short and efficient synthesis of (+)-pilocarpine (1) has been accomplished in 10 steps and 51percent overall yield from L-aspartic acid.The synthesis features a diastereoselective alkylation of a protected aspartic acid diester derivative and a selective hydrolysis of the α-methyl ester to give the corresponding amino acid.Subsequent replacement of the amino group with bromo, esterification, and a modified Reformatsky reaction with 1-methylimidazole-5-carboxaldehyde (8) afforded imidazole-substituted lactone 28.Details concerning this novel lactone synthesis are also described.Finally, hydrogenolysis of the lactone carbon-oxygen bond and selective reduction of the resulting monoester afforded pure (+)-pilocarpine (1).