38993-86-1Relevant academic research and scientific papers
Total synthesis of (+)-pilosinine via a stereodivergent conjugate addition strategy
Schrank, Cassandra L.,Danneman, Michael W.,Prebihalo, Emily A.,Anderson, Robert E.,Gibson, Tyler J.,Wuest, William M.,Mullins, Richard J.
supporting information, (2020/04/27)
In recent work, asymmetric conjugate addition reactions to chiral 4-phenyl-N-enoyl-1,3-oxazolidinones have been shown to give different stereochemical outcomes depending on the conditions employed. Through the application of stereodivergent reaction conditions, the total synthesis of (+)-pilosinine and the formal synthesis of (?)-pilosinine has been completed from a single enantiomer of the 1,3-oxazolidinone auxiliary.
Asymmetric synthesis of (+)pilosinine: A formal synthesis of (+)-pilocarpine
Shapiro, Gideon,Chengzhi, Cai
, p. 2447 - 2450 (2007/10/02)
An efficient asymmetric synthesis of enantiomerically pure (+)-pilosinine achieved in 6 steps from a known chiral bromoacyloxazolidinone.
